Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: a single oral dose study before and after surgery

Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metoprolol from...

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Veröffentlicht in:	European journal of hospital pharmacy. Science and practice 2020-03, Vol.27 (e1), p.e19-e24
Hauptverfasser:	Yska, Jan Peter, Wanders, Jacquelien T M, Odigie, Blessing, Apers, Jan A, Emous, Marloes, Totté, Erik R E, Boerma, E Christiaan, Ubels, Froukje L, Woerdenbag, Herman J, Frijlink, Henderik W, Wilffert, Bob, van Roon, Eric N
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina pectoris Bioavailability Drug dosages Dumping syndrome Gastrointestinal surgery Metabolism Metabolites Original Research Patients Pharmacokinetics
Online-Zugang:	Volltext
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