Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is considered a worldwide healthcare problem that mirrors the increased prevalence of obesity. Gut microbiota plays a crucial role in the progression and treatment of NAFLD. Bofutsushosan (BTS), a pharmaceutical-grade Japanese traditional medicine, has long...
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| Veröffentlicht in: | Nutrients 2020-03, Vol.12 (3), p.839 |
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| creator | Nishiyama, Mitsue Ohtake, Nobuhiro Kaneko, Atsushi Tsuchiya, Naoko Imamura, Sachiko Iizuka, Seiichi Ishizawa, Shiori Nishi, Akinori Yamamoto, Masahiro Taketomi, Akinobu Kono, Toru |
| description | Non-alcoholic fatty liver disease (NAFLD) is considered a worldwide healthcare problem that mirrors the increased prevalence of obesity. Gut microbiota plays a crucial role in the progression and treatment of NAFLD. Bofutsushosan (BTS), a pharmaceutical-grade Japanese traditional medicine, has long been prescribed in Japan for obesity and obesity-related syndrome. Although BTS has been reported to exert an anti-obesity effect in obese patients as well as various obesity-model animals, its effect on gut microbiota is unknown. Here, the effects of BTS on obesity, liver damage, and the gut microbiome in genetically obese mice, ob/ob, were studied. Seven-week-old ob/ob mice were fed a standard diet with (BTS group) or without (CONT group) 5% BTS for 4 weeks. By comparison to the CONT group, the BTS group showed reduced body weight gain and hyperlipidemia as well as improved liver function. Moreover, gut microbiota in the CONT and BTS group formed a significantly different cluster. Specifically, the genera
,
and an unknown genus of the family
expanded dramatically in the BTS group. Noteworthy, the population of
, which is reported to elicit an anti-obesity effect and improve various metabolic abnormalities, was markedly increased (93-fold) compared with the CONT group. These results imply that BTS may be a promising agent for treating NAFLD. |
| doi_str_mv | 10.3390/nu12030839 |
| format | Article |
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,
and an unknown genus of the family
expanded dramatically in the BTS group. Noteworthy, the population of
, which is reported to elicit an anti-obesity effect and improve various metabolic abnormalities, was markedly increased (93-fold) compared with the CONT group. These results imply that BTS may be a promising agent for treating NAFLD.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12030839</identifier><identifier>PMID: 32245128</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abnormalities ; Akkermansia ; Akkermansia muciniphila ; Animal Feed - microbiology ; Animal models ; Animals ; Bile ; Biodiversity ; Biomarkers ; Biopsy ; Body Weight ; Body weight gain ; Cluster analysis ; Deoxyribonucleic acid ; Diet ; Dietary Supplements ; Disease Models, Animal ; DNA ; Drugs, Chinese Herbal - administration & dosage ; Eating ; Fatty liver ; Gastrointestinal Microbiome ; Humans ; Hyperlipidemia ; Immunohistochemistry ; Intestinal microflora ; Kinases ; Laboratory animals ; Liver ; Liver diseases ; Medicine ; Metabolism ; Metabolites ; Metagenome ; Metagenomics - methods ; Mice ; Mice, Obese ; Microbiomes ; Microbiota ; Non-alcoholic Fatty Liver Disease - etiology ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - pathology ; Non-alcoholic Fatty Liver Disease - prevention & control ; Obesity ; Taxonomy ; Weight reduction</subject><ispartof>Nutrients, 2020-03, Vol.12 (3), p.839</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-566fabc2fd366b206eab93556a4e2398b2f073eead093ee2af0f562abb2436423</citedby><cites>FETCH-LOGICAL-c472t-566fabc2fd366b206eab93556a4e2398b2f073eead093ee2af0f562abb2436423</cites><orcidid>0000-0002-3878-1290</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146306/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146306/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32245128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishiyama, Mitsue</creatorcontrib><creatorcontrib>Ohtake, Nobuhiro</creatorcontrib><creatorcontrib>Kaneko, Atsushi</creatorcontrib><creatorcontrib>Tsuchiya, Naoko</creatorcontrib><creatorcontrib>Imamura, Sachiko</creatorcontrib><creatorcontrib>Iizuka, Seiichi</creatorcontrib><creatorcontrib>Ishizawa, Shiori</creatorcontrib><creatorcontrib>Nishi, Akinori</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Taketomi, Akinobu</creatorcontrib><creatorcontrib>Kono, Toru</creatorcontrib><title>Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Non-alcoholic fatty liver disease (NAFLD) is considered a worldwide healthcare problem that mirrors the increased prevalence of obesity. Gut microbiota plays a crucial role in the progression and treatment of NAFLD. Bofutsushosan (BTS), a pharmaceutical-grade Japanese traditional medicine, has long been prescribed in Japan for obesity and obesity-related syndrome. Although BTS has been reported to exert an anti-obesity effect in obese patients as well as various obesity-model animals, its effect on gut microbiota is unknown. Here, the effects of BTS on obesity, liver damage, and the gut microbiome in genetically obese mice, ob/ob, were studied. Seven-week-old ob/ob mice were fed a standard diet with (BTS group) or without (CONT group) 5% BTS for 4 weeks. By comparison to the CONT group, the BTS group showed reduced body weight gain and hyperlipidemia as well as improved liver function. Moreover, gut microbiota in the CONT and BTS group formed a significantly different cluster. Specifically, the genera
,
and an unknown genus of the family
expanded dramatically in the BTS group. Noteworthy, the population of
, which is reported to elicit an anti-obesity effect and improve various metabolic abnormalities, was markedly increased (93-fold) compared with the CONT group. These results imply that BTS may be a promising agent for treating NAFLD.</description><subject>Abnormalities</subject><subject>Akkermansia</subject><subject>Akkermansia muciniphila</subject><subject>Animal Feed - microbiology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bile</subject><subject>Biodiversity</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Body Weight</subject><subject>Body weight gain</subject><subject>Cluster analysis</subject><subject>Deoxyribonucleic acid</subject><subject>Diet</subject><subject>Dietary Supplements</subject><subject>Disease Models, Animal</subject><subject>DNA</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Eating</subject><subject>Fatty liver</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Hyperlipidemia</subject><subject>Immunohistochemistry</subject><subject>Intestinal microflora</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metagenome</subject><subject>Metagenomics - methods</subject><subject>Mice</subject><subject>Mice, Obese</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Non-alcoholic Fatty Liver Disease - etiology</subject><subject>Non-alcoholic Fatty Liver Disease - metabolism</subject><subject>Non-alcoholic Fatty Liver Disease - pathology</subject><subject>Non-alcoholic Fatty Liver Disease - prevention & control</subject><subject>Obesity</subject><subject>Taxonomy</subject><subject>Weight reduction</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkcFu1DAQhi1ERavSCw-ALHFBSAFnnDjJBWlZKLTaLZdyjibJpOvWsbe2U2lfhafFq5ZS6stY42_--T3D2JtcfJSyEZ_snIOQopbNC3YEooJMqUK-fHI_ZCchXIv9qUSl5Ct2KAGKMof6iP0-s70nDMTdyBc3N-QntEEjn-ZeW73daIO823HkXzVFvnQ2YsrbK36OW7SUCi89DjpqZ9HwNQ061RH_4sY5hjlsXEDLtU0Cazcneu0GMvtmF85mC9O7jTO656cY446v9B351CnsHb1mByOaQCcP8Zj9Ov12ufyRrX5-P1suVllfVBCzUqkRux7GQSrVgVCEXSPLUmFBIJu6g1FUkggH0aQAOIqxVIBdB4VUBchj9vledzt3Ew092ejRtFuvJ_S71qFu_3-xetNeubu2ygslhUoC7x8EvLudKcR20qEnY9J80p9bkLWCGirIE_ruGXrtZp8ml6gCRF4p0YhEfbineu9C8DQ-mslFu996-2_rCX771P4j-nfH8g-ERamw</recordid><startdate>20200320</startdate><enddate>20200320</enddate><creator>Nishiyama, Mitsue</creator><creator>Ohtake, Nobuhiro</creator><creator>Kaneko, Atsushi</creator><creator>Tsuchiya, Naoko</creator><creator>Imamura, Sachiko</creator><creator>Iizuka, Seiichi</creator><creator>Ishizawa, Shiori</creator><creator>Nishi, Akinori</creator><creator>Yamamoto, Masahiro</creator><creator>Taketomi, Akinobu</creator><creator>Kono, Toru</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3878-1290</orcidid></search><sort><creationdate>20200320</creationdate><title>Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease</title><author>Nishiyama, Mitsue ; Ohtake, Nobuhiro ; Kaneko, Atsushi ; Tsuchiya, Naoko ; Imamura, Sachiko ; Iizuka, Seiichi ; Ishizawa, Shiori ; Nishi, Akinori ; Yamamoto, Masahiro ; Taketomi, Akinobu ; Kono, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-566fabc2fd366b206eab93556a4e2398b2f073eead093ee2af0f562abb2436423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Akkermansia</topic><topic>Akkermansia muciniphila</topic><topic>Animal Feed - microbiology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Bile</topic><topic>Biodiversity</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Body Weight</topic><topic>Body weight gain</topic><topic>Cluster analysis</topic><topic>Deoxyribonucleic acid</topic><topic>Diet</topic><topic>Dietary Supplements</topic><topic>Disease Models, Animal</topic><topic>DNA</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Eating</topic><topic>Fatty liver</topic><topic>Gastrointestinal Microbiome</topic><topic>Humans</topic><topic>Hyperlipidemia</topic><topic>Immunohistochemistry</topic><topic>Intestinal microflora</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metagenome</topic><topic>Metagenomics - methods</topic><topic>Mice</topic><topic>Mice, Obese</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Non-alcoholic Fatty Liver Disease - etiology</topic><topic>Non-alcoholic Fatty Liver Disease - metabolism</topic><topic>Non-alcoholic Fatty Liver Disease - pathology</topic><topic>Non-alcoholic Fatty Liver Disease - prevention & control</topic><topic>Obesity</topic><topic>Taxonomy</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishiyama, Mitsue</creatorcontrib><creatorcontrib>Ohtake, Nobuhiro</creatorcontrib><creatorcontrib>Kaneko, Atsushi</creatorcontrib><creatorcontrib>Tsuchiya, Naoko</creatorcontrib><creatorcontrib>Imamura, Sachiko</creatorcontrib><creatorcontrib>Iizuka, Seiichi</creatorcontrib><creatorcontrib>Ishizawa, Shiori</creatorcontrib><creatorcontrib>Nishi, Akinori</creatorcontrib><creatorcontrib>Yamamoto, Masahiro</creatorcontrib><creatorcontrib>Taketomi, Akinobu</creatorcontrib><creatorcontrib>Kono, Toru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishiyama, Mitsue</au><au>Ohtake, Nobuhiro</au><au>Kaneko, Atsushi</au><au>Tsuchiya, Naoko</au><au>Imamura, Sachiko</au><au>Iizuka, Seiichi</au><au>Ishizawa, Shiori</au><au>Nishi, Akinori</au><au>Yamamoto, Masahiro</au><au>Taketomi, Akinobu</au><au>Kono, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-03-20</date><risdate>2020</risdate><volume>12</volume><issue>3</issue><spage>839</spage><pages>839-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Non-alcoholic fatty liver disease (NAFLD) is considered a worldwide healthcare problem that mirrors the increased prevalence of obesity. Gut microbiota plays a crucial role in the progression and treatment of NAFLD. Bofutsushosan (BTS), a pharmaceutical-grade Japanese traditional medicine, has long been prescribed in Japan for obesity and obesity-related syndrome. Although BTS has been reported to exert an anti-obesity effect in obese patients as well as various obesity-model animals, its effect on gut microbiota is unknown. Here, the effects of BTS on obesity, liver damage, and the gut microbiome in genetically obese mice, ob/ob, were studied. Seven-week-old ob/ob mice were fed a standard diet with (BTS group) or without (CONT group) 5% BTS for 4 weeks. By comparison to the CONT group, the BTS group showed reduced body weight gain and hyperlipidemia as well as improved liver function. Moreover, gut microbiota in the CONT and BTS group formed a significantly different cluster. Specifically, the genera
,
and an unknown genus of the family
expanded dramatically in the BTS group. Noteworthy, the population of
, which is reported to elicit an anti-obesity effect and improve various metabolic abnormalities, was markedly increased (93-fold) compared with the CONT group. These results imply that BTS may be a promising agent for treating NAFLD.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32245128</pmid><doi>10.3390/nu12030839</doi><orcidid>https://orcid.org/0000-0002-3878-1290</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Abnormalities Akkermansia Akkermansia muciniphila Animal Feed - microbiology Animal models Animals Bile Biodiversity Biomarkers Biopsy Body Weight Body weight gain Cluster analysis Deoxyribonucleic acid Diet Dietary Supplements Disease Models, Animal DNA Drugs, Chinese Herbal - administration & dosage Eating Fatty liver Gastrointestinal Microbiome Humans Hyperlipidemia Immunohistochemistry Intestinal microflora Kinases Laboratory animals Liver Liver diseases Medicine Metabolism Metabolites Metagenome Metagenomics - methods Mice Mice, Obese Microbiomes Microbiota Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Obesity Taxonomy Weight reduction |
| title | Increase of Akkermansia muciniphila by a Diet Containing Japanese Traditional Medicine Bofutsushosan in a Mouse Model of Non-Alcoholic Fatty Liver Disease |
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