Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation
Chronic exposure to cisplatin is associated with irreversible kidney impairment. In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube ( , Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithe...
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| Veröffentlicht in: | Nutrients 2020-03, Vol.12 (3), p.677 |
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| creator | Lee, Dahae Kang, Kyo Bin Kim, Hyun Woo Park, Jung Sik Hwang, Gwi Seo Kang, Ki Sung Choi, Sungyoul Yamabe, Noriko Kim, Ki Hyun |
| description | Chronic exposure to cisplatin is associated with irreversible kidney impairment. In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube (
, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial LLC-PK1 cells, western blotting and staining with specific autophagy epifluorescent dye CytoID were used to determine the molecular pathways involving autophagy. Treatment with 3DC2ME reduced the increased Cyto-ID-stained autophagic vesicles and reversed the protein expressions of 5' AMP-activated protein kinase subunit β-1 (AMPK)/mammalian target of rapamycin (mTOR)-dependent signaling pathway in cisplatin-induced cell death. Additionally, treatment with autophagy inhibitor 3-methyladenine (3-MA) and with or without 3DC2ME attenuated the cisplatin-induced apoptosis. Although further research is necessary to substantiate the effects, we evaluated the potential mechanism of action of 3DC2ME as an adjuvant for cancer patients. |
| doi_str_mv | 10.3390/nu12030677 |
| format | Article |
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, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial LLC-PK1 cells, western blotting and staining with specific autophagy epifluorescent dye CytoID were used to determine the molecular pathways involving autophagy. Treatment with 3DC2ME reduced the increased Cyto-ID-stained autophagic vesicles and reversed the protein expressions of 5' AMP-activated protein kinase subunit β-1 (AMPK)/mammalian target of rapamycin (mTOR)-dependent signaling pathway in cisplatin-induced cell death. Additionally, treatment with autophagy inhibitor 3-methyladenine (3-MA) and with or without 3DC2ME attenuated the cisplatin-induced apoptosis. Although further research is necessary to substantiate the effects, we evaluated the potential mechanism of action of 3DC2ME as an adjuvant for cancer patients.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - metabolism</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute Kidney Injury - prevention & control</subject><subject>AMP-activated protein kinase</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antifungal agents</subject><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Autophagy - drug effects</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Cell Line</subject><subject>Chemotherapy</subject><subject>Chromatography</subject><subject>Chronic exposure</subject><subject>Cisplatin</subject><subject>Cisplatin - adverse effects</subject><subject>Cisplatin - pharmacology</subject><subject>Cytotoxicity</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - pathology</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Kinases</subject><subject>Life sciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phagocytosis</subject><subject>Phytochemicals</subject><subject>Plant Roots - chemistry</subject><subject>Proteins</subject><subject>Rapamycin</subject><subject>Signal transduction</subject><subject>Swine</subject><subject>TOR protein</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - pharmacology</subject><subject>Variance analysis</subject><subject>Western blotting</subject><subject>Ziziphus - chemistry</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkU1rGzEQhkVoaIKTS35AEPRW2EYfu5J9KYSN2yYxJAT7LLTaWVtmLW31EfCtP71rkqbJXGZgXp55mRehC0q-cT4jVy5TRjgRUh6hU0YkK4Qo-ad38wk6j3FLDiWJFPwzOuGMclrR2Sn6s3L2dwa8DDZBGMB522Lf4bu8zQ3gJ-8Tfgw-gUkR1zYOvU7WFda12UCLb_ROrwFbh-9t62CP54NNG-it7vFiUReP9xTX0PcRP1uNr3Pyw0av9_gJ1vlA8u4MHXe6j3D-2ido9WO-rH8Vi4eft_X1ojAlEakQ045r1jVGQjuFqtIl7UyptYamlB2bNt20opzMqAQ5I6JqjeENAyaY0I0RwCfo-wt3yM0OWgMuBd2rIdidDnvltVUfN85u1No_K0lLwSoyAr68AoIfPxaT2voc3OhZsZIRKiWvylH19UVlgo8xQPd2gRJ1CEz9D2wUX7739Cb9Fw__C7Zxksg</recordid><startdate>20200302</startdate><enddate>20200302</enddate><creator>Lee, Dahae</creator><creator>Kang, Kyo Bin</creator><creator>Kim, Hyun Woo</creator><creator>Park, Jung Sik</creator><creator>Hwang, Gwi Seo</creator><creator>Kang, Ki Sung</creator><creator>Choi, Sungyoul</creator><creator>Yamabe, Noriko</creator><creator>Kim, Ki Hyun</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3290-1017</orcidid><orcidid>https://orcid.org/0000-0002-5285-9138</orcidid></search><sort><creationdate>20200302</creationdate><title>Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation</title><author>Lee, Dahae ; 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In this present study, we explored the protective effects of 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME) isolated from roots of jujube (
, Rhamnaceae) against cisplatin-induced damage in vitro. In kidney epithelial LLC-PK1 cells, western blotting and staining with specific autophagy epifluorescent dye CytoID were used to determine the molecular pathways involving autophagy. Treatment with 3DC2ME reduced the increased Cyto-ID-stained autophagic vesicles and reversed the protein expressions of 5' AMP-activated protein kinase subunit β-1 (AMPK)/mammalian target of rapamycin (mTOR)-dependent signaling pathway in cisplatin-induced cell death. Additionally, treatment with autophagy inhibitor 3-methyladenine (3-MA) and with or without 3DC2ME attenuated the cisplatin-induced apoptosis. Although further research is necessary to substantiate the effects, we evaluated the potential mechanism of action of 3DC2ME as an adjuvant for cancer patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32131519</pmid><doi>10.3390/nu12030677</doi><orcidid>https://orcid.org/0000-0003-3290-1017</orcidid><orcidid>https://orcid.org/0000-0002-5285-9138</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control AMP-activated protein kinase Animals Antibodies Antifungal agents Apoptosis Autophagy Autophagy - drug effects Cancer Cell death Cell Line Chemotherapy Chromatography Chronic exposure Cisplatin Cisplatin - adverse effects Cisplatin - pharmacology Cytotoxicity Epithelial Cells - metabolism Epithelial Cells - pathology Kidney - metabolism Kidney - pathology Kidneys Kinases Life sciences NMR Nuclear magnetic resonance Phagocytosis Phytochemicals Plant Roots - chemistry Proteins Rapamycin Signal transduction Swine TOR protein Triterpenes - chemistry Triterpenes - pharmacology Variance analysis Western blotting Ziziphus - chemistry |
| title | Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation |
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