Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 ( g / g ) in a Surgically Induced Osteoarthritic Rabbit Model
In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 ( / ) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee...
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| Veröffentlicht in: | Nutrients 2020-03, Vol.12 (3), p.852 |
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| creator | Choi, Beom-Rak Kang, Su-Jin Kim, Jong-Lae Lee, Young-Joon Ku, Sae-Kwang |
| description | In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (
/
) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were monitored, along with serum collagen type II C-telopeptide (CTX-II), cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and subchondral IL-1β and TNF-α levels. Roentgenographic images were also evaluated. PCP:EC:AR significantly inhibited the surgically induced increase in knee thickness, maximum extension of both knees, knee thickness after capsule exposure, gross femoral and tibial articular defect areas, loss of the knee joint area, serum and synovial COMP, CTX-II, and MMP expression, and synovial IL-1β, and TNF-α expression. In addition, surgically induced narrowing of the knee bones, loss of the joint area, cartilage damage, and osteophyte formation were reduced. PCP:EC:AR suppressed the surgically induced increases in the Mankin score, and subchondral IL-1β and TNF-α immunolabeled cell numbers. PCP:EC:AR exerted potent OA protective effects in a surgically induced OA rabbit model. |
| doi_str_mv | 10.3390/nu12030852 |
| format | Article |
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) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were monitored, along with serum collagen type II C-telopeptide (CTX-II), cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and subchondral IL-1β and TNF-α levels. Roentgenographic images were also evaluated. PCP:EC:AR significantly inhibited the surgically induced increase in knee thickness, maximum extension of both knees, knee thickness after capsule exposure, gross femoral and tibial articular defect areas, loss of the knee joint area, serum and synovial COMP, CTX-II, and MMP expression, and synovial IL-1β, and TNF-α expression. In addition, surgically induced narrowing of the knee bones, loss of the joint area, cartilage damage, and osteophyte formation were reduced. PCP:EC:AR suppressed the surgically induced increases in the Mankin score, and subchondral IL-1β and TNF-α immunolabeled cell numbers. PCP:EC:AR exerted potent OA protective effects in a surgically induced OA rabbit model.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu12030852</identifier><identifier>PMID: 32235804</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Achyranthes ; Administration, Oral ; Animals ; Biomarkers ; Biomarkers - blood ; Biomedical materials ; Cartilage ; Cartilage diseases ; Cartilage oligomeric matrix protein ; Cartilage, Articular - pathology ; Collagen ; Collagen (type II) ; Collagen Type II - blood ; Cytokines ; Cytokines - blood ; Disease Models, Animal ; Drug dosages ; Drugs, Chinese Herbal - administration & dosage ; Eucommiaceae ; IL-1β ; Joints (anatomy) ; Knee ; Laboratory animals ; Ligaments ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 3 - blood ; Matrix metalloproteinases ; Matrix protein ; Metabolism ; Metalloproteinase ; Oral administration ; Osteoarthritis ; Osteoarthritis - diagnosis ; Osteoarthritis - drug therapy ; Osteoarthritis - pathology ; Peptide Fragments - blood ; Phytotherapy ; Pomegranate ; Powders ; Rabbits ; Rodents ; Surgery ; Sutures ; Synergistic effect ; Thickness ; Treatment Outcome ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Nutrients, 2020-03, Vol.12 (3), p.852</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-426b65aa41172e12bc01bca4bf5f7a69cbf2d3aa94907da6038211d2b739514c3</citedby><cites>FETCH-LOGICAL-c336t-426b65aa41172e12bc01bca4bf5f7a69cbf2d3aa94907da6038211d2b739514c3</cites><orcidid>0000-0001-6439-9987 ; 0000-0003-1269-3804</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146119/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146119/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32235804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Beom-Rak</creatorcontrib><creatorcontrib>Kang, Su-Jin</creatorcontrib><creatorcontrib>Kim, Jong-Lae</creatorcontrib><creatorcontrib>Lee, Young-Joon</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><title>Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 ( g / g ) in a Surgically Induced Osteoarthritic Rabbit Model</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (
/
) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were monitored, along with serum collagen type II C-telopeptide (CTX-II), cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and subchondral IL-1β and TNF-α levels. Roentgenographic images were also evaluated. PCP:EC:AR significantly inhibited the surgically induced increase in knee thickness, maximum extension of both knees, knee thickness after capsule exposure, gross femoral and tibial articular defect areas, loss of the knee joint area, serum and synovial COMP, CTX-II, and MMP expression, and synovial IL-1β, and TNF-α expression. In addition, surgically induced narrowing of the knee bones, loss of the joint area, cartilage damage, and osteophyte formation were reduced. PCP:EC:AR suppressed the surgically induced increases in the Mankin score, and subchondral IL-1β and TNF-α immunolabeled cell numbers. PCP:EC:AR exerted potent OA protective effects in a surgically induced OA rabbit model.</description><subject>Achyranthes</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomedical materials</subject><subject>Cartilage</subject><subject>Cartilage diseases</subject><subject>Cartilage oligomeric matrix protein</subject><subject>Cartilage, Articular - pathology</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Collagen Type II - blood</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Disease Models, Animal</subject><subject>Drug dosages</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Eucommiaceae</subject><subject>IL-1β</subject><subject>Joints (anatomy)</subject><subject>Knee</subject><subject>Laboratory animals</subject><subject>Ligaments</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 3 - blood</subject><subject>Matrix metalloproteinases</subject><subject>Matrix protein</subject><subject>Metabolism</subject><subject>Metalloproteinase</subject><subject>Oral administration</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - diagnosis</subject><subject>Osteoarthritis - drug therapy</subject><subject>Osteoarthritis - pathology</subject><subject>Peptide Fragments - blood</subject><subject>Phytotherapy</subject><subject>Pomegranate</subject><subject>Powders</subject><subject>Rabbits</subject><subject>Rodents</subject><subject>Surgery</subject><subject>Sutures</subject><subject>Synergistic effect</subject><subject>Thickness</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkt9qFDEUxgdRbKm98QEk4E2Vjs2_SXZ6ISzrqoWWlqrX4UyS2U2ZSdoko7sP57s5w9ZaGwg54fzOd86BryheE_yBsRqf-IFQzPCsos-KfYolLYXg7PmjeK84TOkGT0diKdjLYo9RyqoZ5vvF77nPrrxM2QaIeR1ddhot29bqnFBoEaALt8lDtNPnU3TWoKvQ21UED9miRfDa-hyn-Cr8MjYeo-WgQ987mLIx280xAm_QXK-3Y1Feu4SuwbgNqk75KUFHaIVOxvsOOT92-zbEldPQdVt05s2gx35PhruGpnEZXQRju1fFixa6ZA_v34Pix-fl98XX8vzyy9lifl5qxkQuORWNqAA4IZJaQhuNSaOBN23VShC1blpqGEDNaywNCMxmlBBDG8nqinDNDoqPO93boemt2a3cqdvoeohbFcCp_zPerdUq_FSScEFIPQoc3QvEcDfYlFXvkrZdB96GISnKZpVklOBqRN8-QW_CEP24nqKcYiJFhelIvd9ROoaUom0fhiFYTcZQ_4wxwm8ej_-A_rUB-wNAX7Oc</recordid><startdate>20200322</startdate><enddate>20200322</enddate><creator>Choi, Beom-Rak</creator><creator>Kang, Su-Jin</creator><creator>Kim, Jong-Lae</creator><creator>Lee, Young-Joon</creator><creator>Ku, Sae-Kwang</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6439-9987</orcidid><orcidid>https://orcid.org/0000-0003-1269-3804</orcidid></search><sort><creationdate>20200322</creationdate><title>Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 ( g / g ) in a Surgically Induced Osteoarthritic Rabbit Model</title><author>Choi, Beom-Rak ; Kang, Su-Jin ; Kim, Jong-Lae ; Lee, Young-Joon ; Ku, Sae-Kwang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-426b65aa41172e12bc01bca4bf5f7a69cbf2d3aa94907da6038211d2b739514c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Achyranthes</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomedical materials</topic><topic>Cartilage</topic><topic>Cartilage diseases</topic><topic>Cartilage oligomeric matrix protein</topic><topic>Cartilage, Articular - pathology</topic><topic>Collagen</topic><topic>Collagen (type II)</topic><topic>Collagen Type II - blood</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Disease Models, Animal</topic><topic>Drug dosages</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Eucommiaceae</topic><topic>IL-1β</topic><topic>Joints (anatomy)</topic><topic>Knee</topic><topic>Laboratory animals</topic><topic>Ligaments</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 3 - blood</topic><topic>Matrix metalloproteinases</topic><topic>Matrix protein</topic><topic>Metabolism</topic><topic>Metalloproteinase</topic><topic>Oral administration</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - diagnosis</topic><topic>Osteoarthritis - drug therapy</topic><topic>Osteoarthritis - pathology</topic><topic>Peptide Fragments - blood</topic><topic>Phytotherapy</topic><topic>Pomegranate</topic><topic>Powders</topic><topic>Rabbits</topic><topic>Rodents</topic><topic>Surgery</topic><topic>Sutures</topic><topic>Synergistic effect</topic><topic>Thickness</topic><topic>Treatment Outcome</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Beom-Rak</creatorcontrib><creatorcontrib>Kang, Su-Jin</creatorcontrib><creatorcontrib>Kim, Jong-Lae</creatorcontrib><creatorcontrib>Lee, Young-Joon</creatorcontrib><creatorcontrib>Ku, Sae-Kwang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Beom-Rak</au><au>Kang, Su-Jin</au><au>Kim, Jong-Lae</au><au>Lee, Young-Joon</au><au>Ku, Sae-Kwang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 ( g / g ) in a Surgically Induced Osteoarthritic Rabbit Model</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-03-22</date><risdate>2020</risdate><volume>12</volume><issue>3</issue><spage>852</spage><pages>852-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>In this study, we aimed to determine the synergistic effects of a formula consisting of dried pomegranate concentrate powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (
/
) (PCP:EC:AR) in a surgically induced osteoarthritis (OA) rabbit model. PCP:EC:AR was orally administered once per day. Knee thickness, maximum extension of the knee joint, gross articular defect area, and the histopathological appearance of the cartilage were monitored, along with serum collagen type II C-telopeptide (CTX-II), cartilage oligomeric matrix protein (COMP), matrix metalloproteinase (MMP)-3, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and subchondral IL-1β and TNF-α levels. Roentgenographic images were also evaluated. PCP:EC:AR significantly inhibited the surgically induced increase in knee thickness, maximum extension of both knees, knee thickness after capsule exposure, gross femoral and tibial articular defect areas, loss of the knee joint area, serum and synovial COMP, CTX-II, and MMP expression, and synovial IL-1β, and TNF-α expression. In addition, surgically induced narrowing of the knee bones, loss of the joint area, cartilage damage, and osteophyte formation were reduced. PCP:EC:AR suppressed the surgically induced increases in the Mankin score, and subchondral IL-1β and TNF-α immunolabeled cell numbers. PCP:EC:AR exerted potent OA protective effects in a surgically induced OA rabbit model.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32235804</pmid><doi>10.3390/nu12030852</doi><orcidid>https://orcid.org/0000-0001-6439-9987</orcidid><orcidid>https://orcid.org/0000-0003-1269-3804</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2020-03, Vol.12 (3), p.852 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Achyranthes Administration, Oral Animals Biomarkers Biomarkers - blood Biomedical materials Cartilage Cartilage diseases Cartilage oligomeric matrix protein Cartilage, Articular - pathology Collagen Collagen (type II) Collagen Type II - blood Cytokines Cytokines - blood Disease Models, Animal Drug dosages Drugs, Chinese Herbal - administration & dosage Eucommiaceae IL-1β Joints (anatomy) Knee Laboratory animals Ligaments Male Matrix metalloproteinase Matrix Metalloproteinase 3 - blood Matrix metalloproteinases Matrix protein Metabolism Metalloproteinase Oral administration Osteoarthritis Osteoarthritis - diagnosis Osteoarthritis - drug therapy Osteoarthritis - pathology Peptide Fragments - blood Phytotherapy Pomegranate Powders Rabbits Rodents Surgery Sutures Synergistic effect Thickness Treatment Outcome Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 ( g / g ) in a Surgically Induced Osteoarthritic Rabbit Model |
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