Are the intrinsically disordered linkers involved in SSB binding to accessory proteins?

Escherichia coli single strand (ss) DNA binding (SSB) protein protects ssDNA intermediates and recruits at least 17 SSB interacting proteins (SIPs) during genome maintenance. The SSB C-termini contain a 9 residue acidic tip and a 56 residue intrinsically disordered linker (IDL). The acidic tip inter...

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Veröffentlicht in:	Nucleic acids research 2019-09, Vol.47 (16), p.8581-8594
Hauptverfasser:	Shinn, Min Kyung, Kozlov, Alexander G, Nguyen, Binh, Bujalowski, Wlodek M, Lohman, Timothy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites DNA Helicases - chemistry DNA Helicases - genetics DNA Helicases - metabolism DNA Polymerase III - chemistry DNA Polymerase III - genetics DNA Polymerase III - metabolism DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Expression Genome Integrity, Repair and Genome, Bacterial Intrinsically Disordered Proteins - chemistry Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism Kinetics Models, Molecular Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Sequence Alignment Sequence Homology, Amino Acid Thermodynamics
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