Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice

The common clinical symptoms of Friedreich’s ataxia (FRDA) include ataxia, muscle weakness, type 2 diabetes and heart failure, which are caused by impaired mitochondrial function due to the loss of frataxin (FXN) expression. Endurance exercise is the most powerful intervention for promoting mitochon...

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Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), p.6095-6095, Article 6095
Hauptverfasser:	Zhao, Henan, Lewellen, Bevan M., Wilson, Rebecca J., Cui, Di, Drake, Joshua C., Zhang, Mei, Yan, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/333 64/60 692/699/317 692/699/75/74 82/80 96/1 Animals Antioxidants Ataxia Congestive heart failure Diabetes mellitus (non-insulin dependent) Electron transport Frataxin Friedreich Ataxia - genetics Friedreich Ataxia - physiopathology Friedreich Ataxia - prevention & control Glucose tolerance Humanities and Social Sciences Intolerance Iron regulatory protein Iron Regulatory Protein 1 - genetics Iron Regulatory Protein 1 - metabolism Iron-Binding Proteins - genetics Mice Mice, Inbred C57BL Mitochondria Mitochondria, Muscle - metabolism multidisciplinary Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Oxidative Stress Physical Conditioning, Animal - methods Physical training Respiratory function Running Science Science (multidisciplinary) Skeletal muscle
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