CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis

Accumulating evidences indicate that 3ʹUTR of the coding gene can act as crucial regulators in gastric cancer (GC). However, the detailed mechanisms and responsive targets are not well established. Here, we found that acvr1b gene 3ʹUTR ( acv 3UTR) was elevated in GC tissue, the expression of which w...

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Veröffentlicht in:	Oncogene 2020-04, Vol.39 (15), p.3075-3088
Hauptverfasser:	Liu, Kai, Wang, Ben-Jun, Han, WeiWei, Chi, Chun-Hua, Gu, Chao, Wang, Yu, Fu, Xiaohai, Huang, Wei, Liu, Zhiguo, Song, Xilin
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics 631/45 631/67/1504/1829 Activin Receptors, Type I - genetics ACVR1B gene Adaptor Proteins, Signal Transducing - genetics Animals Apoptosis Carcinogenesis - genetics Care and treatment Cell Biology Cell Line, Tumor Cell Proliferation - genetics Cleavage And Polyadenylation Specificity Factor - metabolism Development and progression Disease Progression Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Human Genetics Humans Internal Medicine Male Medicine Medicine & Public Health Mice MicroRNA MicroRNAs - metabolism Middle Aged Oncology Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Stomach - pathology Stomach cancer Stomach Neoplasms - genetics Transcription Transcription Factors - genetics Transcription, Genetic Tumor suppressor genes Tumorigenesis Xenograft Model Antitumor Assays Yes-associated protein
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