Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that reduced locus coeruleus (LC) norepinephrine (NE) activity during sleep mediates unresponsiveness, and its action promotes sensory-evoked...

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Veröffentlicht in:	Science advances 2020-04, Vol.6 (15), p.eaaz4232-eaaz4232
Hauptverfasser:	Hayat, Hanna, Regev, Noa, Matosevich, Noa, Sales, Anna, Paredes-Rodriguez, Elena, Krom, Aaron J, Bergman, Lottem, Li, Yong, Lavigne, Marina, Kremer, Eric J, Yizhar, Ofer, Pickering, Anthony E, Nir, Yuval
Format:	Artikel
Sprache:	eng
Schlagworte:	Arousal Electrophysiological Phenomena Life Sciences Locus Coeruleus Locus Coeruleus - physiology Neurobiology Neurons Neurons - physiology Neurons and Cognition Neuroscience Norepinephrine Norepinephrine - metabolism Optogenetics SciAdv r-articles Signal Transduction Sleep Sleep Stages Sound
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