On the magnetic field dependence of deuterium metabolic imaging

Deuterium metabolic imaging (DMI) is a novel MR‐based method to spatially map metabolism of deuterated substrates such as [6,6'‐2H2]‐glucose in vivo. Compared with traditional 13C‐MR‐based metabolic studies, the MR sensitivity of DMI is high due to the larger 2H magnetic moment and favorable T1...

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Veröffentlicht in:NMR in biomedicine 2020-03, Vol.33 (3), p.e4235-n/a
Hauptverfasser: Graaf, Robin A., Hendriks, Arjan D., Klomp, Dennis W.J., Kumaragamage, Chathura, Welting, Dimitri, Arteaga de Castro, Catalina S., Brown, Peter B., McIntyre, Scott, Nixon, Terence W., Prompers, Jeanine J., De Feyter, Henk M.
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container_issue 3
container_start_page e4235
container_title NMR in biomedicine
container_volume 33
creator Graaf, Robin A.
Hendriks, Arjan D.
Klomp, Dennis W.J.
Kumaragamage, Chathura
Welting, Dimitri
Arteaga de Castro, Catalina S.
Brown, Peter B.
McIntyre, Scott
Nixon, Terence W.
Prompers, Jeanine J.
De Feyter, Henk M.
description Deuterium metabolic imaging (DMI) is a novel MR‐based method to spatially map metabolism of deuterated substrates such as [6,6'‐2H2]‐glucose in vivo. Compared with traditional 13C‐MR‐based metabolic studies, the MR sensitivity of DMI is high due to the larger 2H magnetic moment and favorable T1 and T2 relaxation times. Here, the magnetic field dependence of DMI sensitivity and transmit efficiency is studied on phantoms and rat brain postmortem at 4, 9.4 and 11.7 T. The sensitivity and spectral resolution on human brain in vivo are investigated at 4 and 7 T before and after an oral dose of [6,6'‐2H2]‐glucose. For small animal surface coils (Ø 30 mm), the experimentally measured sensitivity and transmit efficiency scale with the magnetic field to a power of +1.75 and −0.30, respectively. These are in excellent agreement with theoretical predictions made from the principle of reciprocity for a coil noise‐dominant regime. For larger human surface coils (Ø 80 mm), the sensitivity scales as a +1.65 power. The spectral resolution increases linearly due to near‐constant linewidths. With optimal multireceiver arrays the acquisition of DMI at a nominal 1 mL spatial resolution is feasible at 7 T. The magnetic field dependence of deuterium metabolic imaging (DMI) sensitivity and RF efficiency was investigated on phantoms in vitro, rat brain postmortem and human brain in vivo. The sensitivity scaled supralinearly, close to the theoretical maximum for all conditions. The enhanced sensitivity at 7 T makes DMI at a nominal 1 mL spatial resolution feasible.
doi_str_mv 10.1002/nbm.4235
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ispartof NMR in biomedicine, 2020-03, Vol.33 (3), p.e4235-n/a
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1099-1492
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source MEDLINE; Access via Wiley Online Library
subjects Animals
Biological products
Brain
Brain - diagnostic imaging
Carbon-13 Magnetic Resonance Spectroscopy
Dependence
Deuteration
Deuterium
Deuterium - metabolism
deuterium metabolic imaging
Glucose
Humans
In vivo methods and tests
magnetic field dependence
Magnetic Fields
Magnetic induction
Magnetic moments
Magnetic Resonance Imaging
Magnetism
Metabolism
Neuroimaging
Phantoms, Imaging
Rats
Reciprocity
resolution
sensitivity
Signal-To-Noise Ratio
Spatial discrimination
Spatial resolution
Spectral resolution
Spectral sensitivity
Substrates
title On the magnetic field dependence of deuterium metabolic imaging
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