Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men
Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospec...
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| Veröffentlicht in: | Journal of clinical medicine 2020-03, Vol.9 (3), p.773 |
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| creator | Oh, Tae Ryom Choi, Hong Sang Kim, Chang Seong Ryu, Dong-Ryeol Park, Sun-Hee Ahn, Shin Young Kim, Soo Wan Bae, Eun Hui Ma, Seong Kwon |
| description | Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan-Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018-1.317;
= 0.028) but not in men (HR, 1.499; CI, 0.964-2.331;
= 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men. |
| doi_str_mv | 10.3390/jcm9030773 |
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= 0.028) but not in men (HR, 1.499; CI, 0.964-2.331;
= 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9030773</identifier><identifier>PMID: 32178386</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Blood pressure ; Clinical medicine ; Creatinine ; Diabetes ; Hospitals ; Hypertension ; Kidney diseases ; Lupus ; Medical prognosis ; Population ; Sexes ; Survival analysis ; Uric acid ; Variables ; Womens health</subject><ispartof>Journal of clinical medicine, 2020-03, Vol.9 (3), p.773</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-62bbd5c48b24cc423cd7f0c21dc89ca8eb301a97905e715404ad115c59d8dda43</citedby><cites>FETCH-LOGICAL-c336t-62bbd5c48b24cc423cd7f0c21dc89ca8eb301a97905e715404ad115c59d8dda43</cites><orcidid>0000-0003-1727-2822 ; 0000-0002-3713-0939 ; 0000-0001-8191-4071 ; 0000-0002-3540-9004 ; 0000-0002-0953-3343</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141287/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141287/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32178386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Tae Ryom</creatorcontrib><creatorcontrib>Choi, Hong Sang</creatorcontrib><creatorcontrib>Kim, Chang Seong</creatorcontrib><creatorcontrib>Ryu, Dong-Ryeol</creatorcontrib><creatorcontrib>Park, Sun-Hee</creatorcontrib><creatorcontrib>Ahn, Shin Young</creatorcontrib><creatorcontrib>Kim, Soo Wan</creatorcontrib><creatorcontrib>Bae, Eun Hui</creatorcontrib><creatorcontrib>Ma, Seong Kwon</creatorcontrib><title>Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Lupus nephritis (LN) is a major complication of systemic lupus erythematosus. Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan-Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018-1.317;
= 0.028) but not in men (HR, 1.499; CI, 0.964-2.331;
= 0.072). Sensitivity analysis involving serum uric acid terciles generated consistent and robust results. Serum uric acid level was an independent risk factor for LN progression in women but not in men.</description><subject>Blood pressure</subject><subject>Clinical medicine</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Kidney diseases</subject><subject>Lupus</subject><subject>Medical prognosis</subject><subject>Population</subject><subject>Sexes</subject><subject>Survival analysis</subject><subject>Uric acid</subject><subject>Variables</subject><subject>Womens health</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUtLAzEUhYMotlQ3_gAJuBGhmkwyTWYjlOIL6gO1uJKQSdI2ZSapyYzivzei1mqyOOHej8MhB4A9jI4JKdDJQtUFIogxsgG6WdI-Ipxsrr07YDfGBUqHc5phtg06JAknfNAFzw8mtDWcBKvgUFkNbYTDGL2ysjEavtlmDu-NkxW8C37mfEx7P4XjdtlGeGOW82CbNLIOPvnaOFi2DXS--RxcG7cDtqayimb3W3tgcn72OLrsj28vrkbDcV8RMmj6g6wsda4oLzOqFM2I0myKVIa14oWS3JQEYVmwAuWG4ZwiKjXGucoLzbWWlPTA6Zfvsi1ro5VxTZCVWAZby_AuvLTi78bZuZj5V8EwxRlnyeDw2yD4l9bERtQ2KlNV0hnfRpERxoqCEpon9OAfuvBtSD-UqAFNsXi6iTr6olTwMQYzXYXBSHwWJ36LS_D-evwV-lMT-QBRS5NC</recordid><startdate>20200312</startdate><enddate>20200312</enddate><creator>Oh, Tae Ryom</creator><creator>Choi, Hong Sang</creator><creator>Kim, Chang Seong</creator><creator>Ryu, Dong-Ryeol</creator><creator>Park, Sun-Hee</creator><creator>Ahn, Shin Young</creator><creator>Kim, Soo Wan</creator><creator>Bae, Eun Hui</creator><creator>Ma, Seong Kwon</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1727-2822</orcidid><orcidid>https://orcid.org/0000-0002-3713-0939</orcidid><orcidid>https://orcid.org/0000-0001-8191-4071</orcidid><orcidid>https://orcid.org/0000-0002-3540-9004</orcidid><orcidid>https://orcid.org/0000-0002-0953-3343</orcidid></search><sort><creationdate>20200312</creationdate><title>Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men</title><author>Oh, Tae Ryom ; 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Early intervention in lupus nephritis improves prognosis. There is an association between hyperuricemia and lupus nephritis; nevertheless, the sex-specific role of uric acid in lupus nephritis remains unclear. We retrospectively analyzed 578 patients diagnosed with LN by renal biopsy. We determine the relationship of serum uric acid to progression of LN using Kaplan-Meier survival analyses and Cox proportional hazards models. The primary end point was LN progression defined as the initiation of dialysis or kidney transplantation. Men had higher mean serum uric acid levels than did women. Every 1 mg/dL increase in baseline uric acid level increased the risk of LN progression by 15.1%. The serum uric acid level was an independent risk factor for LN progression in women (hazard ratio [HR], 1.158; confidence interval [CI], 1.018-1.317;
= 0.028) but not in men (HR, 1.499; CI, 0.964-2.331;
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| ispartof | Journal of clinical medicine, 2020-03, Vol.9 (3), p.773 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Blood pressure Clinical medicine Creatinine Diabetes Hospitals Hypertension Kidney diseases Lupus Medical prognosis Population Sexes Survival analysis Uric acid Variables Womens health |
| title | Serum Uric Acid is Associated with Renal Prognosis of Lupus Nephritis in Women but not in Men |
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