Regulation of Necroptosis by Phospholipids and Sphingolipids

Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggest...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2020-03, Vol.9 (3), p.627, Article 627
Hauptverfasser:	Zhang, Xuewei, Matsuda, Masaya, Yaegashi, Nobuo, Nabe, Takeshi, Kitatani, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biology ceramide Ceramides - genetics Ceramides - metabolism fatty acids Humans Life Sciences & Biomedicine lipids mixed lineage kinase-domain like necroptosis Necroptosis - physiology phosphatidylinositols Phospholipids - metabolism Protein Kinases - metabolism Receptor-Interacting Protein Serine-Threonine Kinases - metabolism Review Science & Technology Sphingolipids - metabolism
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Beschreibung
Zusammenfassung:	Several non-apoptotic regulated cell death pathways have been recently reported. Necroptosis, a form of necrotic-regulated cell death, is characterized by the involvement of receptor-interacting protein kinases and/or the pore-forming mixed lineage kinase domain-like protein. Recent evidence suggests a key role for lipidic molecules in the regulation of necroptosis. The purpose of this mini-review is to outline the regulation of necroptosis by sphingolipids and phospholipids.
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells9030627