Analysis of the Rule of TCM Compatibility in TCM Prescriptions Containing Ginseng Radix ET Rhizoma in Ancient Books for Xiaoke Bing
Background. TCM considers that diabetes belongs to the scope of Xiaoke Bing. Compound prescriptions are characteristics of TCM. For a certain medicine, its compatibility with different medicines can exert different efficacies in different prescriptions. Using the TCM compound prescriptions containin...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-7 |
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| creator | Liu, Shuying Wang, ShuHua Zhang, Bo Sun, Xiuli Zhou, Qingying |
| description | Background. TCM considers that diabetes belongs to the scope of Xiaoke Bing. Compound prescriptions are characteristics of TCM. For a certain medicine, its compatibility with different medicines can exert different efficacies in different prescriptions. Using the TCM compound prescriptions containing Ginseng Radix ET Rhizoma in ancient books for Xiaoke Bing as an example, this study introduces new methods to investigate the rule of TCM compatibility. Methods. Frequency analysis was accomplished by programs written in Perl. The R, Cytoscape, and DpClus software were used to carry out the association rules analysis, the construction of the TCM interconnection network, and the graph clustering analysis, respectively. Results. Frequency analysis ranked the frequencies of medicine, medicinal flavors, properties, and meridian attributions, and it was found that some of them are significantly higher than others. Six association rules were obtained. The TCM interconnection network showed that there are close medicine associations among prescriptions, and we got 17 categories of closely related prescriptions from the network. Conclusions. Ginseng Radix ET Rhizoma was widely used in treating Xiaoke Bing. Our results are consistent with the understanding of Xiaoke Bing in TCM; hence, it is demonstrated that the methods are effective for exploring the rule of TCM usage in prescriptions. This analysis could provide references for the treatment of diabetes. |
| doi_str_mv | 10.1155/2020/9472304 |
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TCM considers that diabetes belongs to the scope of Xiaoke Bing. Compound prescriptions are characteristics of TCM. For a certain medicine, its compatibility with different medicines can exert different efficacies in different prescriptions. Using the TCM compound prescriptions containing Ginseng Radix ET Rhizoma in ancient books for Xiaoke Bing as an example, this study introduces new methods to investigate the rule of TCM compatibility. Methods. Frequency analysis was accomplished by programs written in Perl. The R, Cytoscape, and DpClus software were used to carry out the association rules analysis, the construction of the TCM interconnection network, and the graph clustering analysis, respectively. Results. Frequency analysis ranked the frequencies of medicine, medicinal flavors, properties, and meridian attributions, and it was found that some of them are significantly higher than others. Six association rules were obtained. The TCM interconnection network showed that there are close medicine associations among prescriptions, and we got 17 categories of closely related prescriptions from the network. Conclusions. Ginseng Radix ET Rhizoma was widely used in treating Xiaoke Bing. Our results are consistent with the understanding of Xiaoke Bing in TCM; hence, it is demonstrated that the methods are effective for exploring the rule of TCM usage in prescriptions. This analysis could provide references for the treatment of diabetes.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/9472304</identifier><identifier>PMID: 32308724</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analysis ; Chinese medicine ; Diabetes ; Diabetes mellitus ; Dictionaries ; Drug dosages ; Ginseng ; Medicine, Chinese ; Open source software ; Prescriptions</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-7</ispartof><rights>Copyright © 2020 Xiuli Sun et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Xiuli Sun et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Xiuli Sun et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-cb23e97465958d8cb422f319d0dd457070a8dac75e1fbc8c3d750376026f8b6f3</citedby><cites>FETCH-LOGICAL-c499t-cb23e97465958d8cb422f319d0dd457070a8dac75e1fbc8c3d750376026f8b6f3</cites><orcidid>0000-0003-3140-7690 ; 0000-0003-3184-5893</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140142/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140142/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32308724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lenon, George B.</contributor><contributor>George B Lenon</contributor><creatorcontrib>Liu, Shuying</creatorcontrib><creatorcontrib>Wang, ShuHua</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Sun, Xiuli</creatorcontrib><creatorcontrib>Zhou, Qingying</creatorcontrib><title>Analysis of the Rule of TCM Compatibility in TCM Prescriptions Containing Ginseng Radix ET Rhizoma in Ancient Books for Xiaoke Bing</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. TCM considers that diabetes belongs to the scope of Xiaoke Bing. Compound prescriptions are characteristics of TCM. For a certain medicine, its compatibility with different medicines can exert different efficacies in different prescriptions. Using the TCM compound prescriptions containing Ginseng Radix ET Rhizoma in ancient books for Xiaoke Bing as an example, this study introduces new methods to investigate the rule of TCM compatibility. Methods. Frequency analysis was accomplished by programs written in Perl. The R, Cytoscape, and DpClus software were used to carry out the association rules analysis, the construction of the TCM interconnection network, and the graph clustering analysis, respectively. Results. Frequency analysis ranked the frequencies of medicine, medicinal flavors, properties, and meridian attributions, and it was found that some of them are significantly higher than others. Six association rules were obtained. The TCM interconnection network showed that there are close medicine associations among prescriptions, and we got 17 categories of closely related prescriptions from the network. Conclusions. Ginseng Radix ET Rhizoma was widely used in treating Xiaoke Bing. Our results are consistent with the understanding of Xiaoke Bing in TCM; hence, it is demonstrated that the methods are effective for exploring the rule of TCM usage in prescriptions. This analysis could provide references for the treatment of diabetes.</description><subject>Analysis</subject><subject>Chinese medicine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Dictionaries</subject><subject>Drug dosages</subject><subject>Ginseng</subject><subject>Medicine, Chinese</subject><subject>Open source software</subject><subject>Prescriptions</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk1vEzEQhlcIREvhxhlZ4oIEof7atX2plEalIBWBoiD1Znm9djLtxg7rXSBc-eN4SUiBE6cZ2c-8M_a8RfGU4NeElOUpxRSfKi4ow_xecUwEJxNOpbx_yMX1UfEopRuMqRJCPCyOWIaloPy4-DENpt0mSCh61K8cmg-tG_PF7D2axfXG9FBDC_0WQfh1-LFzyXaw6SGGlJHQGwgQlugSQnI5zk0D39DFAs1X8D2uzVg4DRZc6NF5jLcJ-dihazDx1qHzXPm4eOBNm9yTfTwpPr25WMzeTq4-XL6bTa8mlivVT2xNmVOCV6UqZSNtzSn1jKgGNw0vBRbYyMZYUTriaysta0SJmagwrbysK89OirOd7mao166xeaDOtHrTwdp0Wx0N6L9vAqz0Mn7RgnBMOM0CL_YCXfw8uNTrNSTr2tYEF4ekKVM0L6JSI_r8H_QmDl3-65GSFWFMSn5HLU3rNAQfc187iuppRbnKK8IqU692lO1iSp3zh5EJ1qMH9OgBvfdAxp_9-cwD_HvpGXi5A1YQGvMV_lPOZcZ5c0eTUpZUsp-Te8Hb</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Liu, Shuying</creator><creator>Wang, ShuHua</creator><creator>Zhang, Bo</creator><creator>Sun, Xiuli</creator><creator>Zhou, Qingying</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3140-7690</orcidid><orcidid>https://orcid.org/0000-0003-3184-5893</orcidid></search><sort><creationdate>2020</creationdate><title>Analysis of the Rule of TCM Compatibility in TCM Prescriptions Containing Ginseng Radix ET Rhizoma in Ancient Books for Xiaoke Bing</title><author>Liu, Shuying ; Wang, ShuHua ; Zhang, Bo ; Sun, Xiuli ; Zhou, Qingying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-cb23e97465958d8cb422f319d0dd457070a8dac75e1fbc8c3d750376026f8b6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analysis</topic><topic>Chinese medicine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Dictionaries</topic><topic>Drug dosages</topic><topic>Ginseng</topic><topic>Medicine, Chinese</topic><topic>Open source software</topic><topic>Prescriptions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Shuying</creatorcontrib><creatorcontrib>Wang, ShuHua</creatorcontrib><creatorcontrib>Zhang, Bo</creatorcontrib><creatorcontrib>Sun, Xiuli</creatorcontrib><creatorcontrib>Zhou, Qingying</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Shuying</au><au>Wang, ShuHua</au><au>Zhang, Bo</au><au>Sun, Xiuli</au><au>Zhou, Qingying</au><au>Lenon, George B.</au><au>George B Lenon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the Rule of TCM Compatibility in TCM Prescriptions Containing Ginseng Radix ET Rhizoma in Ancient Books for Xiaoke Bing</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. TCM considers that diabetes belongs to the scope of Xiaoke Bing. Compound prescriptions are characteristics of TCM. For a certain medicine, its compatibility with different medicines can exert different efficacies in different prescriptions. Using the TCM compound prescriptions containing Ginseng Radix ET Rhizoma in ancient books for Xiaoke Bing as an example, this study introduces new methods to investigate the rule of TCM compatibility. Methods. Frequency analysis was accomplished by programs written in Perl. The R, Cytoscape, and DpClus software were used to carry out the association rules analysis, the construction of the TCM interconnection network, and the graph clustering analysis, respectively. Results. Frequency analysis ranked the frequencies of medicine, medicinal flavors, properties, and meridian attributions, and it was found that some of them are significantly higher than others. Six association rules were obtained. The TCM interconnection network showed that there are close medicine associations among prescriptions, and we got 17 categories of closely related prescriptions from the network. Conclusions. Ginseng Radix ET Rhizoma was widely used in treating Xiaoke Bing. Our results are consistent with the understanding of Xiaoke Bing in TCM; hence, it is demonstrated that the methods are effective for exploring the rule of TCM usage in prescriptions. This analysis could provide references for the treatment of diabetes.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32308724</pmid><doi>10.1155/2020/9472304</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3140-7690</orcidid><orcidid>https://orcid.org/0000-0003-3184-5893</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Chinese medicine Diabetes Diabetes mellitus Dictionaries Drug dosages Ginseng Medicine, Chinese Open source software Prescriptions |
| title | Analysis of the Rule of TCM Compatibility in TCM Prescriptions Containing Ginseng Radix ET Rhizoma in Ancient Books for Xiaoke Bing |
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