Proton Pump Inhibitors Reduce Pancreatic Adenocarcinoma Progression by Selectively Targeting H + , K + -ATPases in Pancreatic Cancer and Stellate Cells

Pancreatic duct cells are equipped with acid/base transporters important for exocrine secretion. Pancreatic ductal adenocarcinoma (PDAC) cells may utilize such transporters to acidify extracellular tumor microenvironment, creating a niche favoring cell proliferation, fibrosis and resistance to chemo...

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Veröffentlicht in:	Cancers 2020-03, Vol.12 (3), p.640
Hauptverfasser:	Tozzi, Marco, Sørensen, Christiane E, Magni, Lara, Christensen, Nynne M, Bouazzi, Rayhana, Buch, Caroline M, Stefanini, Matteo, Duranti, Claudia, Arcangeli, Annarosa, Novak, Ivana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenocarcinoma Angiogenesis Cell cycle Cell growth Cell proliferation Chemotherapy Collagen Cyclin D1 Fibrosis Hydrogen Localization Pancreatic cancer Potassium Potassium conductance Proteins Proton pump inhibitors Secretion Stat3 protein Stellate cells Tumors
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