Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition

Mitochondria putatively regulate the aging process, in part, through the small regulatory peptide, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) that is encoded by the mitochondrial genome. Here we investigated the regulation of MOTS-c in the plasma and skeletal muscle of healthy aging...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-03, Vol.12 (6), p.5244-5258
Hauptverfasser:	D'Souza, Randall F, Woodhead, Jonathan S T, Hedges, Christopher P, Zeng, Nina, Wan, Junxiang, Kumagai, Hiroshi, Lee, Changhan, Cohen, Pinchas, Cameron-Smith, David, Mitchell, Cameron J, Merry, Troy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - metabolism Healthy Aging - metabolism Humans Male Middle Aged Mitochondria - metabolism Mitochondrial Proteins - blood Muscle, Skeletal - metabolism Peptides - metabolism Research Paper RNA, Ribosomal Transcription Factors - metabolism
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