Corosolic acid attenuates cardiac fibrosis following myocardial infarction in mice

Corosolic acid (CRA) is a pentacyclic triterpenoid isolated from Lagerstroemia speciosa. The aim of the present study was to determine whether CRA reduces cardiac remodelling following myocardial infarction (MI) and to elucidate the underlying mechanisms. C57BL/6J mice were randomly divided into con...

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Veröffentlicht in:	International journal of molecular medicine 2020-05, Vol.45 (5), p.1425-1435
Hauptverfasser:	Wang, Zhao-Peng, Che, Yan, Zhou, Heng, Meng, Yan-Yan, Wu, Hai-Ming, Jin, Ya-Ge, Wu, Qing-Qing, Wang, Sha-Sha, Yuan, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol AMP-Activated Protein Kinases - metabolism Animals Apoptosis Apoptosis - drug effects Catheters Cell Line Coronary vessels Disease Models, Animal Echocardiography - methods Fibrosis - drug therapy Fibrosis - metabolism Heart - drug effects Heart attacks Hydrochloric acid Inflammation - drug therapy Inflammation - metabolism Kinases Laboratory animals Male Mice Mice, Inbred C57BL Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Myocardium - metabolism Ostomy Oxidative stress Oxidative Stress - drug effects Phosphorylation Phosphorylation - drug effects Proteins Rats Signal Transduction - drug effects Surgery Triterpenes - pharmacology Veins & arteries Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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