Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques
Abstract Background Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the testis and epididymis, and these results has been co...
Gespeichert in:
| Veröffentlicht in: | The Journal of infectious diseases 2020-04, Vol.221 (9), p.1506-1517 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1517 |
|---|---|
| container_issue | 9 |
| container_start_page | 1506 |
| container_title | The Journal of infectious diseases |
| container_volume | 221 |
| creator | Halabi, Jacques Jagger, Brett W Salazar, Vanessa Winkler, Emma S White, James P Humphrey, Peter A Hirsch, Alec J Streblow, Daniel N Diamond, Michael S Moley, Kelle |
| description | Abstract
Background
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the testis and epididymis, and these results has been correlated to lower sperm counts in ZIKV-infected humans. The prostate plays a vital role in the male reproductive tract, with acute and chronic prostatitis linked to male infertility.
Methods
In this study, we evaluated the effects of ZIKV virus on the prostate in mice and nonhuman primates.
Results
In mice, ZIKV infected the prostate and triggered inflammation that persisted even after virus clearance. Evidence of chronic prostatitis associated with ZIKV infection remained for several months. Similar histological findings were observed in the prostate of ZIKV-infected rhesus macaques.
Conclusions
These studies establish that ZIKV replicates in the prostate and can cause acute and chronic inflammatory and proliferative changes in mouse and nonhuman primate models.
Although ZIKV can be transmitted sexually and target the testis for infection, its effect on the prostate is less well appreciated. We evaluated the acute and chronic effects of ZIKV infection in the prostate of mice and rhesus macaques. |
| doi_str_mv | 10.1093/infdis/jiz533 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7137895</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/infdis/jiz533</oup_id><sourcerecordid>2448683910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-7a70856fa2ab69dcfdc50f8d20b921ba7930930a5886a2bdef32300f9747513a3</originalsourceid><addsrcrecordid>eNqFkTtPwzAUhS0EoqUwsqJILCyhfjR2vCBV5Sm1ggEYWKwbx6EubVLsBAl-Pa5SymNhusP9dO459yB0SPApwZL1bVnk1vdn9iNhbAt1ScJEzDlh26iLMaUxSaXsoD3vZxjjAeNiF3UY4YRLirvo_Mm-QPRoXeOjETTe-Giom9pEUObRaOqq0urozlW-htrW1ke2jCZWt_sJaHhtjN9HOwXMvTlYzx56uLy4H13H49urm9FwHOvBIK1jAQKnCS-AQsZlrotcJ7hIc4ozSUkGQrKQCEOSphxolpuCUYZxIcVAJIQB66GzVnfZZAuTa1PWDuZq6ewC3LuqwKrfm9JO1XP1pgRhIpVJEDhZC7hqZbxWC-u1mc-hNFXjVTjHKUmk5AE9_oPOqsaVIZ6iIQ1PmSQ4UHFL6fAi70yxMUOwWvWj2n5U20_gj34m2NBfhXw7rJrlP1qfLLqa6w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2448683910</pqid></control><display><type>article</type><title>Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Halabi, Jacques ; Jagger, Brett W ; Salazar, Vanessa ; Winkler, Emma S ; White, James P ; Humphrey, Peter A ; Hirsch, Alec J ; Streblow, Daniel N ; Diamond, Michael S ; Moley, Kelle</creator><creatorcontrib>Halabi, Jacques ; Jagger, Brett W ; Salazar, Vanessa ; Winkler, Emma S ; White, James P ; Humphrey, Peter A ; Hirsch, Alec J ; Streblow, Daniel N ; Diamond, Michael S ; Moley, Kelle</creatorcontrib><description>Abstract
Background
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the testis and epididymis, and these results has been correlated to lower sperm counts in ZIKV-infected humans. The prostate plays a vital role in the male reproductive tract, with acute and chronic prostatitis linked to male infertility.
Methods
In this study, we evaluated the effects of ZIKV virus on the prostate in mice and nonhuman primates.
Results
In mice, ZIKV infected the prostate and triggered inflammation that persisted even after virus clearance. Evidence of chronic prostatitis associated with ZIKV infection remained for several months. Similar histological findings were observed in the prostate of ZIKV-infected rhesus macaques.
Conclusions
These studies establish that ZIKV replicates in the prostate and can cause acute and chronic inflammatory and proliferative changes in mouse and nonhuman primate models.
Although ZIKV can be transmitted sexually and target the testis for infection, its effect on the prostate is less well appreciated. We evaluated the acute and chronic effects of ZIKV infection in the prostate of mice and rhesus macaques.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiz533</identifier><identifier>PMID: 31616920</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Acute Disease ; Animal models ; Animals ; Chronic Disease ; Chronic infection ; Disease Models, Animal ; Disease transmission ; Epididymis ; Infertility ; Inflammation ; Macaca mulatta ; Major and Brief Reports ; Male ; Mice ; Mice, Inbred C57BL ; Primates ; Prostate ; Prostatitis ; Prostatitis - pathology ; Prostatitis - virology ; Reproductive system ; Semen - virology ; Testis - pathology ; Testis - virology ; Zika Virus ; Zika Virus Infection - complications ; Zika Virus Infection - transmission</subject><ispartof>The Journal of infectious diseases, 2020-04, Vol.221 (9), p.1506-1517</ispartof><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-7a70856fa2ab69dcfdc50f8d20b921ba7930930a5886a2bdef32300f9747513a3</citedby><cites>FETCH-LOGICAL-c448t-7a70856fa2ab69dcfdc50f8d20b921ba7930930a5886a2bdef32300f9747513a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1583,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31616920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halabi, Jacques</creatorcontrib><creatorcontrib>Jagger, Brett W</creatorcontrib><creatorcontrib>Salazar, Vanessa</creatorcontrib><creatorcontrib>Winkler, Emma S</creatorcontrib><creatorcontrib>White, James P</creatorcontrib><creatorcontrib>Humphrey, Peter A</creatorcontrib><creatorcontrib>Hirsch, Alec J</creatorcontrib><creatorcontrib>Streblow, Daniel N</creatorcontrib><creatorcontrib>Diamond, Michael S</creatorcontrib><creatorcontrib>Moley, Kelle</creatorcontrib><title>Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Abstract
Background
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the testis and epididymis, and these results has been correlated to lower sperm counts in ZIKV-infected humans. The prostate plays a vital role in the male reproductive tract, with acute and chronic prostatitis linked to male infertility.
Methods
In this study, we evaluated the effects of ZIKV virus on the prostate in mice and nonhuman primates.
Results
In mice, ZIKV infected the prostate and triggered inflammation that persisted even after virus clearance. Evidence of chronic prostatitis associated with ZIKV infection remained for several months. Similar histological findings were observed in the prostate of ZIKV-infected rhesus macaques.
Conclusions
These studies establish that ZIKV replicates in the prostate and can cause acute and chronic inflammatory and proliferative changes in mouse and nonhuman primate models.
Although ZIKV can be transmitted sexually and target the testis for infection, its effect on the prostate is less well appreciated. We evaluated the acute and chronic effects of ZIKV infection in the prostate of mice and rhesus macaques.</description><subject>Acute Disease</subject><subject>Animal models</subject><subject>Animals</subject><subject>Chronic Disease</subject><subject>Chronic infection</subject><subject>Disease Models, Animal</subject><subject>Disease transmission</subject><subject>Epididymis</subject><subject>Infertility</subject><subject>Inflammation</subject><subject>Macaca mulatta</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Primates</subject><subject>Prostate</subject><subject>Prostatitis</subject><subject>Prostatitis - pathology</subject><subject>Prostatitis - virology</subject><subject>Reproductive system</subject><subject>Semen - virology</subject><subject>Testis - pathology</subject><subject>Testis - virology</subject><subject>Zika Virus</subject><subject>Zika Virus Infection - complications</subject><subject>Zika Virus Infection - transmission</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtPwzAUhS0EoqUwsqJILCyhfjR2vCBV5Sm1ggEYWKwbx6EubVLsBAl-Pa5SymNhusP9dO459yB0SPApwZL1bVnk1vdn9iNhbAt1ScJEzDlh26iLMaUxSaXsoD3vZxjjAeNiF3UY4YRLirvo_Mm-QPRoXeOjETTe-Giom9pEUObRaOqq0urozlW-htrW1ke2jCZWt_sJaHhtjN9HOwXMvTlYzx56uLy4H13H49urm9FwHOvBIK1jAQKnCS-AQsZlrotcJ7hIc4ozSUkGQrKQCEOSphxolpuCUYZxIcVAJIQB66GzVnfZZAuTa1PWDuZq6ewC3LuqwKrfm9JO1XP1pgRhIpVJEDhZC7hqZbxWC-u1mc-hNFXjVTjHKUmk5AE9_oPOqsaVIZ6iIQ1PmSQ4UHFL6fAi70yxMUOwWvWj2n5U20_gj34m2NBfhXw7rJrlP1qfLLqa6w</recordid><startdate>20200407</startdate><enddate>20200407</enddate><creator>Halabi, Jacques</creator><creator>Jagger, Brett W</creator><creator>Salazar, Vanessa</creator><creator>Winkler, Emma S</creator><creator>White, James P</creator><creator>Humphrey, Peter A</creator><creator>Hirsch, Alec J</creator><creator>Streblow, Daniel N</creator><creator>Diamond, Michael S</creator><creator>Moley, Kelle</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200407</creationdate><title>Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques</title><author>Halabi, Jacques ; Jagger, Brett W ; Salazar, Vanessa ; Winkler, Emma S ; White, James P ; Humphrey, Peter A ; Hirsch, Alec J ; Streblow, Daniel N ; Diamond, Michael S ; Moley, Kelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-7a70856fa2ab69dcfdc50f8d20b921ba7930930a5886a2bdef32300f9747513a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Disease</topic><topic>Animal models</topic><topic>Animals</topic><topic>Chronic Disease</topic><topic>Chronic infection</topic><topic>Disease Models, Animal</topic><topic>Disease transmission</topic><topic>Epididymis</topic><topic>Infertility</topic><topic>Inflammation</topic><topic>Macaca mulatta</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Primates</topic><topic>Prostate</topic><topic>Prostatitis</topic><topic>Prostatitis - pathology</topic><topic>Prostatitis - virology</topic><topic>Reproductive system</topic><topic>Semen - virology</topic><topic>Testis - pathology</topic><topic>Testis - virology</topic><topic>Zika Virus</topic><topic>Zika Virus Infection - complications</topic><topic>Zika Virus Infection - transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halabi, Jacques</creatorcontrib><creatorcontrib>Jagger, Brett W</creatorcontrib><creatorcontrib>Salazar, Vanessa</creatorcontrib><creatorcontrib>Winkler, Emma S</creatorcontrib><creatorcontrib>White, James P</creatorcontrib><creatorcontrib>Humphrey, Peter A</creatorcontrib><creatorcontrib>Hirsch, Alec J</creatorcontrib><creatorcontrib>Streblow, Daniel N</creatorcontrib><creatorcontrib>Diamond, Michael S</creatorcontrib><creatorcontrib>Moley, Kelle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halabi, Jacques</au><au>Jagger, Brett W</au><au>Salazar, Vanessa</au><au>Winkler, Emma S</au><au>White, James P</au><au>Humphrey, Peter A</au><au>Hirsch, Alec J</au><au>Streblow, Daniel N</au><au>Diamond, Michael S</au><au>Moley, Kelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2020-04-07</date><risdate>2020</risdate><volume>221</volume><issue>9</issue><spage>1506</spage><epage>1517</epage><pages>1506-1517</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Background
Sexual transmission and persistence of Zika virus (ZIKV) in the male reproductive tract has raised concerned for potential damaging effects on function. Animal studies have demonstrated that ZIKV virus can infect and damage the testis and epididymis, and these results has been correlated to lower sperm counts in ZIKV-infected humans. The prostate plays a vital role in the male reproductive tract, with acute and chronic prostatitis linked to male infertility.
Methods
In this study, we evaluated the effects of ZIKV virus on the prostate in mice and nonhuman primates.
Results
In mice, ZIKV infected the prostate and triggered inflammation that persisted even after virus clearance. Evidence of chronic prostatitis associated with ZIKV infection remained for several months. Similar histological findings were observed in the prostate of ZIKV-infected rhesus macaques.
Conclusions
These studies establish that ZIKV replicates in the prostate and can cause acute and chronic inflammatory and proliferative changes in mouse and nonhuman primate models.
Although ZIKV can be transmitted sexually and target the testis for infection, its effect on the prostate is less well appreciated. We evaluated the acute and chronic effects of ZIKV infection in the prostate of mice and rhesus macaques.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31616920</pmid><doi>10.1093/infdis/jiz533</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 2020-04, Vol.221 (9), p.1506-1517 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7137895 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Acute Disease Animal models Animals Chronic Disease Chronic infection Disease Models, Animal Disease transmission Epididymis Infertility Inflammation Macaca mulatta Major and Brief Reports Male Mice Mice, Inbred C57BL Primates Prostate Prostatitis Prostatitis - pathology Prostatitis - virology Reproductive system Semen - virology Testis - pathology Testis - virology Zika Virus Zika Virus Infection - complications Zika Virus Infection - transmission |
| title | Zika Virus Causes Acute and Chronic Prostatitis in Mice and Macaques |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T10%3A26%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Zika%20Virus%20Causes%20Acute%20and%20Chronic%20Prostatitis%20in%20Mice%20and%20Macaques&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Halabi,%20Jacques&rft.date=2020-04-07&rft.volume=221&rft.issue=9&rft.spage=1506&rft.epage=1517&rft.pages=1506-1517&rft.issn=0022-1899&rft.eissn=1537-6613&rft_id=info:doi/10.1093/infdis/jiz533&rft_dat=%3Cproquest_pubme%3E2448683910%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2448683910&rft_id=info:pmid/31616920&rft_oup_id=10.1093/infdis/jiz533&rfr_iscdi=true |