Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

Mutations in the Parkinson's disease (PD)-associated protein leucine-rich repeat kinase 2 (LRRK2) commonly lead to a reduction of GTPase activity and increase in kinase activity. Therefore, strategies for drug development have mainly been focusing on the design of LRRK2 kinase inhibitors. We re...

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Veröffentlicht in:	Biochemical journal 2020-04, Vol.477 (7), p.1203-1218
Hauptverfasser:	Leemans, Margaux, Galicia, Christian, Deyaert, Egon, Daems, Elise, Krause, Linda, Paesmans, Jone, Pardon, Els, Steyaert, Jan, Kortholt, Arjan, Sobott, Frank, Klostermeier, Dagmar, Versées, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Biophysics Enzymology Molecular Bases of Health & Disease
Online-Zugang:	Volltext
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