Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage

BACKGROUND AND PURPOSE—Enhancement of erythrophagocytosis by macrophages in a timely manner can limit the toxic effects of erythrocyte metabolites and promote brain recovery after intracerebral hemorrhage (ICH). In the current study, we investigated the therapeutic effect of retinoid X receptor agon...

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Veröffentlicht in:	Stroke (1970) 2020-02, Vol.51 (2), p.612-618
Hauptverfasser:	Chang, Che-Feng, Massey, Jordan, Osherov, Artem, Angenendt da Costa, Luís Henrique, Sansing, Lauren H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bexarotene - pharmacology Brain - drug effects Brain - pathology Cerebral Hemorrhage - drug therapy Disease Models, Animal Erythrocytes - drug effects Erythrocytes - pathology Hematoma - drug therapy Hematoma - metabolism Macrophages - drug effects Macrophages - metabolism Microglia - drug effects Phagocytosis - drug effects
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