Contagious bovine pleuropneumonia: A rationale for the development of a mucosal sub-unit vaccine
Abstract Contagious bovine pleuropneumonia (CBPP) remains a major cattle disease in Africa with serious socio-economic consequences. Its eradication requires the development of improved vaccines. Knowledge on this disease and its causing agent, Mycoplasma mycoides subsp. mycoides biotype Small Colon...
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| Veröffentlicht in: | Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2008-03, Vol.31 (2), p.227-238 |
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| description | Abstract Contagious bovine pleuropneumonia (CBPP) remains a major cattle disease in Africa with serious socio-economic consequences. Its eradication requires the development of improved vaccines. Knowledge on this disease and its causing agent, Mycoplasma mycoides subsp. mycoides biotype Small Colony ( Mmm SC), has been progressing significantly in the last years, opening new areas for vaccine design. Advances were achieved in the understanding of the protective immune responses to Mmm SC infection and immunopathological mechanisms allowing the pathogen to escape the host immune response. Based on sequencing and genomic studies, some virulence factors and metabolic pathways were unraveled leading to the identification of potential Mmm SC vaccine candidates. Based on these findings, this review presents a scientific strategy to design multi-component sub-unit vaccines for mucosal delivery as the most promising approach for efficient long-term protective vaccines to prevent CBPP. |
| doi_str_mv | 10.1016/j.cimid.2007.07.009 |
| format | Article |
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Its eradication requires the development of improved vaccines. Knowledge on this disease and its causing agent, Mycoplasma mycoides subsp. mycoides biotype Small Colony ( Mmm SC), has been progressing significantly in the last years, opening new areas for vaccine design. Advances were achieved in the understanding of the protective immune responses to Mmm SC infection and immunopathological mechanisms allowing the pathogen to escape the host immune response. Based on sequencing and genomic studies, some virulence factors and metabolic pathways were unraveled leading to the identification of potential Mmm SC vaccine candidates. Based on these findings, this review presents a scientific strategy to design multi-component sub-unit vaccines for mucosal delivery as the most promising approach for efficient long-term protective vaccines to prevent CBPP.</description><identifier>ISSN: 0147-9571</identifier><identifier>EISSN: 1878-1667</identifier><identifier>DOI: 10.1016/j.cimid.2007.07.009</identifier><identifier>PMID: 17706775</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Antigènes vaccinaux ; Bacterial Vaccines - administration & dosage ; Cattle ; Drug Administration Routes - veterinary ; Immune responses ; Infectious Disease ; Life Sciences ; Mucosal vaccines ; Mycoplasma mycoides ; Mycoplasma mycoides - immunology ; Mycoplasma mycoides subsp. mycoides SC ( MmmSC) ; Mycoplasmas ; Mycoplasmes ; Oral vaccines ; Pleuropneumonia, Contagious - prevention & control ; Péripneumonie contagieuse bovine (PPCB) ; Réponse immunitaire ; Sub-unit vaccines ; Vaccine antigens ; Vaccines, Subunit - administration & dosage ; Vaccins muqueux ; Vaccins oraux ; Vaccins sous-unitaires</subject><ispartof>Comparative immunology, microbiology and infectious diseases, 2008-03, Vol.31 (2), p.227-238</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2007 Elsevier Ltd. All rights reserved. 2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c608t-747b51e94818f3d4d6cae4588cc013e2b8bb38a324565c4472bf7f5f5a3bc6fc3</citedby><cites>FETCH-LOGICAL-c608t-747b51e94818f3d4d6cae4588cc013e2b8bb38a324565c4472bf7f5f5a3bc6fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0147957107000732$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17706775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02660440$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Dedieu-Engelmann, Laurence</creatorcontrib><title>Contagious bovine pleuropneumonia: A rationale for the development of a mucosal sub-unit vaccine</title><title>Comparative immunology, microbiology and infectious diseases</title><addtitle>Comp Immunol Microbiol Infect Dis</addtitle><description>Abstract Contagious bovine pleuropneumonia (CBPP) remains a major cattle disease in Africa with serious socio-economic consequences. Its eradication requires the development of improved vaccines. Knowledge on this disease and its causing agent, Mycoplasma mycoides subsp. mycoides biotype Small Colony ( Mmm SC), has been progressing significantly in the last years, opening new areas for vaccine design. Advances were achieved in the understanding of the protective immune responses to Mmm SC infection and immunopathological mechanisms allowing the pathogen to escape the host immune response. Based on sequencing and genomic studies, some virulence factors and metabolic pathways were unraveled leading to the identification of potential Mmm SC vaccine candidates. Based on these findings, this review presents a scientific strategy to design multi-component sub-unit vaccines for mucosal delivery as the most promising approach for efficient long-term protective vaccines to prevent CBPP.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antigènes vaccinaux</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Cattle</subject><subject>Drug Administration Routes - veterinary</subject><subject>Immune responses</subject><subject>Infectious Disease</subject><subject>Life Sciences</subject><subject>Mucosal vaccines</subject><subject>Mycoplasma mycoides</subject><subject>Mycoplasma mycoides - immunology</subject><subject>Mycoplasma mycoides subsp. mycoides SC ( MmmSC)</subject><subject>Mycoplasmas</subject><subject>Mycoplasmes</subject><subject>Oral vaccines</subject><subject>Pleuropneumonia, Contagious - prevention & control</subject><subject>Péripneumonie contagieuse bovine (PPCB)</subject><subject>Réponse immunitaire</subject><subject>Sub-unit vaccines</subject><subject>Vaccine antigens</subject><subject>Vaccines, Subunit - 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| ispartof | Comparative immunology, microbiology and infectious diseases, 2008-03, Vol.31 (2), p.227-238 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Allergy and Immunology Animals Antigènes vaccinaux Bacterial Vaccines - administration & dosage Cattle Drug Administration Routes - veterinary Immune responses Infectious Disease Life Sciences Mucosal vaccines Mycoplasma mycoides Mycoplasma mycoides - immunology Mycoplasma mycoides subsp. mycoides SC ( MmmSC) Mycoplasmas Mycoplasmes Oral vaccines Pleuropneumonia, Contagious - prevention & control Péripneumonie contagieuse bovine (PPCB) Réponse immunitaire Sub-unit vaccines Vaccine antigens Vaccines, Subunit - administration & dosage Vaccins muqueux Vaccins oraux Vaccins sous-unitaires |
| title | Contagious bovine pleuropneumonia: A rationale for the development of a mucosal sub-unit vaccine |
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