Hippocampal CD39/ENTPD1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP

Emerging evidence implicates that low levels of ATP in the extracellular space may contribute to the pathophysiology of major depressive disorder (MDD). The concentration of extracellular ATP is regulated by its hydrolase ectonucleotide tri(di)phosphohydrolase (ENTPD). However, the role of ENTPD in...

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Veröffentlicht in:	EMBO reports 2020-04, Vol.21 (4), p.e47857-n/a
Hauptverfasser:	Cui, Qian‐Qian, Hu, Zhuang‐Li, Hu, Yuan‐Lang, Chen, Xi, Wang, Ji, Mao, Li, Lu, Xiao‐Jia, Ni, Ming, Chen, Jian‐Guo, Wang, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Antidepressants Apyrase Apyrase - genetics Apyrase - metabolism ATP CD39 CSDS Dendritic spines Depression - genetics Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics EMBO27 Hippocampus Hippocampus - metabolism Hydrolase Mental depression Mice Mice, Inbred C57BL Neurogenesis Pharmacology Phosphohydrolase Replenishment Social behavior Social interactions Spine
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