Targeted and proteome-wide analysis of metabolite–protein interactions
Understanding the molecular mechanisms of endogenous and environmental metabolites is crucial for basic biology and drug discovery. With the genome, proteome, and metabolome of many organisms being readily available, researchers now have the opportunity to dissect how key metabolites regulate comple...
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| Veröffentlicht in: | Current opinion in chemical biology 2020-02, Vol.54, p.19-27 |
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| container_title | Current opinion in chemical biology |
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| creator | Tsukidate, Taku Li, Qiang Hang, Howard C. |
| description | Understanding the molecular mechanisms of endogenous and environmental metabolites is crucial for basic biology and drug discovery. With the genome, proteome, and metabolome of many organisms being readily available, researchers now have the opportunity to dissect how key metabolites regulate complex cellular pathways in vivo. Nonetheless, characterizing the specific and functional protein targets of key metabolites associated with specific cellular phenotypes remains a major challenge. Innovations in chemical biology are now poised to address this fundamental limitation in physiology and disease. In this review, we highlight recent advances in chemoproteomics for targeted and proteome-wide analysis of metabolite–protein interactions that have enabled the discovery of unpredicted metabolite–protein interactions and facilitated the development of new small molecule therapeutics. |
| doi_str_mv | 10.1016/j.cbpa.2019.10.008 |
| format | Article |
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| ispartof | Current opinion in chemical biology, 2020-02, Vol.54, p.19-27 |
| issn | 1367-5931 1879-0402 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Chemical reporter Humans Metabolite Metabolome - physiology Metabolomics - methods Proteins - chemistry Proteins - metabolism Proteome - chemistry Proteome - metabolism Proteomics Proteomics - methods |
| title | Targeted and proteome-wide analysis of metabolite–protein interactions |
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