Vaccine-induced enhancement of viral infections
Abstract Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vacc...
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| Veröffentlicht in: | Vaccine 2009-01, Vol.27 (4), p.505-512 |
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| creator | Huisman, W Martina, B.E.E Rimmelzwaan, G.F Gruters, R.A Osterhaus, A.D.M.E |
| description | Abstract Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis. |
| doi_str_mv | 10.1016/j.vaccine.2008.10.087 |
| format | Article |
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Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.10.087</identifier><identifier>PMID: 19022319</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>ADE ; Allergy and Immunology ; Animals ; Antibodies ; Applied microbiology ; Biological and medical sciences ; Dengue fever ; Dengue virus ; Disease Susceptibility - etiology ; Encephalitis ; Enhancement ; Families & family life ; Feline coronavirus ; Feline immunodeficiency virus ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Immune system ; Immunity, Cellular - immunology ; Infections ; Lentivirus ; Lentivirus Infections - immunology ; Lentivirus Infections - prevention & control ; Measles ; Microbiology ; Miscellaneous ; Monkeys & apes ; Pathogenesis ; Respiratory syncytial virus ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vector-borne diseases ; Viral infections ; Viral Vaccines - administration & dosage ; Viral Vaccines - adverse effects ; Virology ; Virus Diseases - immunology ; Virus Diseases - virology ; Virus Internalization ; Virus Replication ; Viruses ; West Nile virus</subject><ispartof>Vaccine, 2009-01, Vol.27 (4), p.505-512</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 22, 2009</rights><rights>Copyright © 2008 Elsevier Ltd. All rights reserved. 2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-342882e9f539e0eff4f411814e2d87400ec083d1c474d1c694882e4410a0e2773</citedby><cites>FETCH-LOGICAL-c609t-342882e9f539e0eff4f411814e2d87400ec083d1c474d1c694882e4410a0e2773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X08015053$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21127699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19022319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huisman, W</creatorcontrib><creatorcontrib>Martina, B.E.E</creatorcontrib><creatorcontrib>Rimmelzwaan, G.F</creatorcontrib><creatorcontrib>Gruters, R.A</creatorcontrib><creatorcontrib>Osterhaus, A.D.M.E</creatorcontrib><title>Vaccine-induced enhancement of viral infections</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.</description><subject>ADE</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Dengue fever</subject><subject>Dengue virus</subject><subject>Disease Susceptibility - etiology</subject><subject>Encephalitis</subject><subject>Enhancement</subject><subject>Families & family life</subject><subject>Feline coronavirus</subject><subject>Feline immunodeficiency virus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity, Cellular - immunology</subject><subject>Infections</subject><subject>Lentivirus</subject><subject>Lentivirus Infections - immunology</subject><subject>Lentivirus Infections - prevention & control</subject><subject>Measles</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Monkeys & apes</subject><subject>Pathogenesis</subject><subject>Respiratory syncytial virus</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vector-borne diseases</subject><subject>Viral infections</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - adverse effects</subject><subject>Virology</subject><subject>Virus Diseases - immunology</subject><subject>Virus Diseases - virology</subject><subject>Virus Internalization</subject><subject>Virus Replication</subject><subject>Viruses</subject><subject>West Nile virus</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk9v1DAQxS0EotvCRwCthOCW7YzjJM6lCFWUIlXqgT_iZhlnTL1knWJvVuq374SNWuillziyf35-M2-EeIWwQsD6eL3aWedCpJUE0Ly3At08EQvUTVnICvVTsQBZq0Ih_DgQhzmvAaAqsX0uDrAFKfl3IY6_71WKELvRUbekeGWjow3F7XLwy11Itl-G6MltwxDzC_HM2z7Ty3k9Et_OPn49PS8uLj99Pv1wUbga2m1RKqm1pNZXZUtA3iuvEDUqkp1uFAA50GWHTjWKv3WrJlyxVwskm6Y8Eid73evx54Y6x3bYiLlOYWPTjRlsMP-fxHBlfg0702CJpaxZ4N0skIY_I-Wt2YTsqO9tpGHMRnJzoPkLvnkArocxRS7OoGqhqiQqZKraUy4NOSfyd1YQzBSIWZs5EDMFMm1zIHzv9b913N-aE2Dg7QzY7GzvE3c_5DtOIsqmbifu_Z4j7vouUDLZBeKkupA4G9MN4VErJw8UXB9i4Ed_0w3l-6pNlgbMl2l6puEBDVjx5JS38Ou_Gw</recordid><startdate>20090122</startdate><enddate>20090122</enddate><creator>Huisman, W</creator><creator>Martina, B.E.E</creator><creator>Rimmelzwaan, G.F</creator><creator>Gruters, R.A</creator><creator>Osterhaus, A.D.M.E</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20090122</creationdate><title>Vaccine-induced enhancement of viral infections</title><author>Huisman, W ; Martina, B.E.E ; Rimmelzwaan, G.F ; Gruters, R.A ; Osterhaus, A.D.M.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-342882e9f539e0eff4f411814e2d87400ec083d1c474d1c694882e4410a0e2773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>ADE</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Dengue fever</topic><topic>Dengue virus</topic><topic>Disease Susceptibility - etiology</topic><topic>Encephalitis</topic><topic>Enhancement</topic><topic>Families & family life</topic><topic>Feline coronavirus</topic><topic>Feline immunodeficiency virus</topic><topic>Fundamental and applied biological sciences. 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A.D.M.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccine-induced enhancement of viral infections</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2009-01-22</date><risdate>2009</risdate><volume>27</volume><issue>4</issue><spage>505</spage><epage>512</epage><pages>505-512</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other. The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19022319</pmid><doi>10.1016/j.vaccine.2008.10.087</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ADE Allergy and Immunology Animals Antibodies Applied microbiology Biological and medical sciences Dengue fever Dengue virus Disease Susceptibility - etiology Encephalitis Enhancement Families & family life Feline coronavirus Feline immunodeficiency virus Fundamental and applied biological sciences. Psychology HIV HIV-1 - physiology Human immunodeficiency virus Humans Immune system Immunity, Cellular - immunology Infections Lentivirus Lentivirus Infections - immunology Lentivirus Infections - prevention & control Measles Microbiology Miscellaneous Monkeys & apes Pathogenesis Respiratory syncytial virus Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vector-borne diseases Viral infections Viral Vaccines - administration & dosage Viral Vaccines - adverse effects Virology Virus Diseases - immunology Virus Diseases - virology Virus Internalization Virus Replication Viruses West Nile virus |
| title | Vaccine-induced enhancement of viral infections |
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