Monoclonal antibodies to the matrix (El) glycoprotein of mouse hepatitis virus protect mice from encephalitis

Monoclonal antibodies to the matrix or El glycoprotein of mouse hepatitis virus (MHV) were tested for their ability to protect mice from a normally lethal challenge of MHV-4. Four antibodies were tested, and two of these,J.1.3 and J.3.9, were protective. Protection did not correlate with virus neutr...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1989, Vol.168 (1), p.162-167
Hauptverfasser:	Fleming, John O., Shubin, Richard A., Sussman, Mark A., Casteel, Nancy, Stohlman, Stephen A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Binding, Competitive Biological and medical sciences Brain - pathology Coronaviridae Infections - prevention & control Encephalitis - prevention & control Fundamental and applied biological sciences. Psychology Glycoproteins - immunology Immunization, Passive Male Mice Mice, Inbred C57BL Microbiology Murine hepatitis virus - immunology Short Communication Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Matrix Proteins - immunology Virology Virus Replication
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