Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan
Background The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of cer...
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| Veröffentlicht in: | Journal of the Chinese Medical Association 2010-02, Vol.73 (2), p.62-66 |
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| creator | Chan, Yu-Jiun Lee, Chia-Ling Hwang, Shinn-Jang Fung, Chang-Phone Wang, Fu-Der Yen, David H.T Tsai, Cheng-Hsien Chen, Yi-Ming Arthur Lee, Shou-Dong |
| description | Background The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group ( p = 0.925). Conclusion The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first. |
| doi_str_mv | 10.1016/S1726-4901(10)70003-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7129009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1726490110700034</els_id><sourcerecordid>744619216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c619t-88467f2492ca26c7c20aa64a50f0b4ce1ea8a8bc3ec6645365007f4d91bbcb8b3</originalsourceid><addsrcrecordid>eNqFkU9v1DAQxSMEoqXwEUC-0R4CY8exk0ur1QrYSuWPtIWr5TiT4pK1FzvZqnx6nE2pgEtPtp7fvJnxL8teUnhDgYq3ayqZyHkN9JjCiQSAIuePssMkV7mUBX28v8-Wg-xZjNcAXNR1-TQ7YEAlLSt-mN2sMfhtwJ3u0RkkviMLN9jGtxYjGTz5ol2LG2vI8Yp-oieEAdTk3HX9iO6XJt9sGCNZbLy7Iisft3bQPVkPuuuIdUSTj9hak6QlugHDpF1qe6Pd8-xJp_uIL-7Oo-zr-3eXy1V-8fnD-XJxkRtB6yGvKi5kx3jNjGbCSMNAa8F1CR003CBFXemqMQUaIXhZiBJAdrytadOYpmqKo-x0zt2OzQZbk8YIulfbYDc63Cqvrfr3xdnv6srvlKSsTqumgNd3AcH_HDEOamOjwb7XDv0YleQ8TcqoeNhZFAXlQrDkLGenCT7GgN39PBTURFft6aoJ3STt6Sqe6l79vcx91R-cyXA2GzB96c5iUNHYiWtrA5pBtd4-2OL0vwTTWzch_IG3GK_9GFzipaiKTMEcMmVQ2Cfw4jfJacio</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733314662</pqid></control><display><type>article</type><title>Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Chan, Yu-Jiun ; Lee, Chia-Ling ; Hwang, Shinn-Jang ; Fung, Chang-Phone ; Wang, Fu-Der ; Yen, David H.T ; Tsai, Cheng-Hsien ; Chen, Yi-Ming Arthur ; Lee, Shou-Dong</creator><creatorcontrib>Chan, Yu-Jiun ; Lee, Chia-Ling ; Hwang, Shinn-Jang ; Fung, Chang-Phone ; Wang, Fu-Der ; Yen, David H.T ; Tsai, Cheng-Hsien ; Chen, Yi-Ming Arthur ; Lee, Shou-Dong</creatorcontrib><description>Background The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group ( p = 0.925). Conclusion The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.</description><identifier>ISSN: 1726-4901</identifier><identifier>EISSN: 1728-7731</identifier><identifier>DOI: 10.1016/S1726-4901(10)70003-4</identifier><identifier>PMID: 20171584</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Antibodies, Viral - blood ; Disease Outbreaks ; Female ; H1N1 influenza virus ; hemagglutination-inhibition test ; hospital staff ; Humans ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza virus ; Influenza, Human - epidemiology ; Internal Medicine ; Male ; Middle Aged ; Original ; Personnel, Hospital ; Seroepidemiologic Studies ; Taiwan - epidemiology ; Time Factors ; Vaccination</subject><ispartof>Journal of the Chinese Medical Association, 2010-02, Vol.73 (2), p.62-66</ispartof><rights>Elsevier</rights><rights>2010 Elsevier</rights><rights>Copyright 2010 Elsevier. Published by Elsevier B.V. All rights reserved.</rights><rights>2010 Elsevier 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-88467f2492ca26c7c20aa64a50f0b4ce1ea8a8bc3ec6645365007f4d91bbcb8b3</citedby><cites>FETCH-LOGICAL-c619t-88467f2492ca26c7c20aa64a50f0b4ce1ea8a8bc3ec6645365007f4d91bbcb8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1726490110700034$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20171584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chan, Yu-Jiun</creatorcontrib><creatorcontrib>Lee, Chia-Ling</creatorcontrib><creatorcontrib>Hwang, Shinn-Jang</creatorcontrib><creatorcontrib>Fung, Chang-Phone</creatorcontrib><creatorcontrib>Wang, Fu-Der</creatorcontrib><creatorcontrib>Yen, David H.T</creatorcontrib><creatorcontrib>Tsai, Cheng-Hsien</creatorcontrib><creatorcontrib>Chen, Yi-Ming Arthur</creatorcontrib><creatorcontrib>Lee, Shou-Dong</creatorcontrib><title>Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan</title><title>Journal of the Chinese Medical Association</title><addtitle>J Chin Med Assoc</addtitle><description>Background The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group ( p = 0.925). Conclusion The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Viral - blood</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>H1N1 influenza virus</subject><subject>hemagglutination-inhibition test</subject><subject>hospital staff</subject><subject>Humans</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza virus</subject><subject>Influenza, Human - epidemiology</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Personnel, Hospital</subject><subject>Seroepidemiologic Studies</subject><subject>Taiwan - epidemiology</subject><subject>Time Factors</subject><subject>Vaccination</subject><issn>1726-4901</issn><issn>1728-7731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxSMEoqXwEUC-0R4CY8exk0ur1QrYSuWPtIWr5TiT4pK1FzvZqnx6nE2pgEtPtp7fvJnxL8teUnhDgYq3ayqZyHkN9JjCiQSAIuePssMkV7mUBX28v8-Wg-xZjNcAXNR1-TQ7YEAlLSt-mN2sMfhtwJ3u0RkkviMLN9jGtxYjGTz5ol2LG2vI8Yp-oieEAdTk3HX9iO6XJt9sGCNZbLy7Iisft3bQPVkPuuuIdUSTj9hak6QlugHDpF1qe6Pd8-xJp_uIL-7Oo-zr-3eXy1V-8fnD-XJxkRtB6yGvKi5kx3jNjGbCSMNAa8F1CR003CBFXemqMQUaIXhZiBJAdrytadOYpmqKo-x0zt2OzQZbk8YIulfbYDc63Cqvrfr3xdnv6srvlKSsTqumgNd3AcH_HDEOamOjwb7XDv0YleQ8TcqoeNhZFAXlQrDkLGenCT7GgN39PBTURFft6aoJ3STt6Sqe6l79vcx91R-cyXA2GzB96c5iUNHYiWtrA5pBtd4-2OL0vwTTWzch_IG3GK_9GFzipaiKTMEcMmVQ2Cfw4jfJacio</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Chan, Yu-Jiun</creator><creator>Lee, Chia-Ling</creator><creator>Hwang, Shinn-Jang</creator><creator>Fung, Chang-Phone</creator><creator>Wang, Fu-Der</creator><creator>Yen, David H.T</creator><creator>Tsai, Cheng-Hsien</creator><creator>Chen, Yi-Ming Arthur</creator><creator>Lee, Shou-Dong</creator><general>Elsevier B.V</general><general>Elsevier. Published by Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan</title><author>Chan, Yu-Jiun ; Lee, Chia-Ling ; Hwang, Shinn-Jang ; Fung, Chang-Phone ; Wang, Fu-Der ; Yen, David H.T ; Tsai, Cheng-Hsien ; Chen, Yi-Ming Arthur ; Lee, Shou-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-88467f2492ca26c7c20aa64a50f0b4ce1ea8a8bc3ec6645365007f4d91bbcb8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Viral - blood</topic><topic>Disease Outbreaks</topic><topic>Female</topic><topic>H1N1 influenza virus</topic><topic>hemagglutination-inhibition test</topic><topic>hospital staff</topic><topic>Humans</topic><topic>Influenza A Virus, H1N1 Subtype - immunology</topic><topic>Influenza virus</topic><topic>Influenza, Human - epidemiology</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Personnel, Hospital</topic><topic>Seroepidemiologic Studies</topic><topic>Taiwan - epidemiology</topic><topic>Time Factors</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Yu-Jiun</creatorcontrib><creatorcontrib>Lee, Chia-Ling</creatorcontrib><creatorcontrib>Hwang, Shinn-Jang</creatorcontrib><creatorcontrib>Fung, Chang-Phone</creatorcontrib><creatorcontrib>Wang, Fu-Der</creatorcontrib><creatorcontrib>Yen, David H.T</creatorcontrib><creatorcontrib>Tsai, Cheng-Hsien</creatorcontrib><creatorcontrib>Chen, Yi-Ming Arthur</creatorcontrib><creatorcontrib>Lee, Shou-Dong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Chinese Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Yu-Jiun</au><au>Lee, Chia-Ling</au><au>Hwang, Shinn-Jang</au><au>Fung, Chang-Phone</au><au>Wang, Fu-Der</au><au>Yen, David H.T</au><au>Tsai, Cheng-Hsien</au><au>Chen, Yi-Ming Arthur</au><au>Lee, Shou-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan</atitle><jtitle>Journal of the Chinese Medical Association</jtitle><addtitle>J Chin Med Assoc</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>73</volume><issue>2</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>1726-4901</issn><eissn>1728-7731</eissn><abstract>Background The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group ( p = 0.925). Conclusion The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20171584</pmid><doi>10.1016/S1726-4901(10)70003-4</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antibodies, Viral - blood Disease Outbreaks Female H1N1 influenza virus hemagglutination-inhibition test hospital staff Humans Influenza A Virus, H1N1 Subtype - immunology Influenza virus Influenza, Human - epidemiology Internal Medicine Male Middle Aged Original Personnel, Hospital Seroepidemiologic Studies Taiwan - epidemiology Time Factors Vaccination |
| title | Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan |
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