Virus-like particles: Passport to immune recognition
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. In many cases such VLPs have structural characteristics and antigenicity similar to the parental virus, and some have already proven successful as vaccines against the cognate virus infe...
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| Veröffentlicht in: | Methods (San Diego, Calif.) Calif.), 2006-09, Vol.40 (1), p.60-65 |
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| container_title | Methods (San Diego, Calif.) |
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| creator | Grgacic, Elizabeth V.L. Anderson, David A. |
| description | Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. In many cases such VLPs have structural characteristics and antigenicity similar to the parental virus, and some have already proven successful as vaccines against the cognate virus infection. The structural components of some VLPs have also proven amenable to the insertion or fusion of foreign antigenic sequences, allowing the production of chimeric VLPs exposing the foreign antigen on their surface. Other VLPs have been used as carriers for foreign antigens, including non-protein antigens, via chemical conjugation. This review outlines some of the advantages, disadvantages, and technical considerations for the use of a wide range of VLP systems in vaccine development. |
| doi_str_mv | 10.1016/j.ymeth.2006.07.018 |
| format | Article |
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This review outlines some of the advantages, disadvantages, and technical considerations for the use of a wide range of VLP systems in vaccine development.</description><subject>Antibody Formation</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Chimeric VLPs</subject><subject>Dendritic Cells - immunology</subject><subject>Immunity, Cellular</subject><subject>Vaccine</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Virosomes - immunology</subject><subject>Virus-like particles</subject><issn>1046-2023</issn><issn>1095-9130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtL5EAQxxtRfH8CQXLylljdnfRDcGGR9QGCHtRrk-lUtGeT9Gx3R_Dbm3GGVS-eqqD-j-JHyBGFggIVp_Pircf0UjAAUYAsgKoNsktBV7mmHDaXeylyBozvkL0Y5wBAmVTbZIcKraWk5S4pn1wYY965v5gt6pCc7TCeZfd1jAsfUpZ85vp-HDALaP3z4JLzwwHZausu4uF67pPHyz8PF9f57d3VzcXv29yWlUy5sBWVTWXBtpWUtpTcMpy1WpSAgiEH0ApsPZvOHHTT8rKstAakCpFrqPg--bXKXYyzHhuLQwp1ZxbB9XV4M7525vtlcC_m2b8aSZlSTE0BJ-uA4P-NGJPpXbTYdfWAfoxGKCWFrNgk5CuhDT7GgO3_EgpmSdvMzQdts6RtQJqJ9uQ6_vrfp2eNdxKcrwQ4UXp1GEy0DgeLjZtwJtN492PBO6aIksA</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Grgacic, Elizabeth V.L.</creator><creator>Anderson, David A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060901</creationdate><title>Virus-like particles: Passport to immune recognition</title><author>Grgacic, Elizabeth V.L. ; Anderson, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-6c517d5c0cf577c473c2ebf9640e62e300980cabcf5309df3445990e18ee39053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antibody Formation</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Chimeric VLPs</topic><topic>Dendritic Cells - immunology</topic><topic>Immunity, Cellular</topic><topic>Vaccine</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Virosomes - immunology</topic><topic>Virus-like particles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grgacic, Elizabeth V.L.</creatorcontrib><creatorcontrib>Anderson, David A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Methods (San Diego, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grgacic, Elizabeth V.L.</au><au>Anderson, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virus-like particles: Passport to immune recognition</atitle><jtitle>Methods (San Diego, Calif.)</jtitle><addtitle>Methods</addtitle><date>2006-09-01</date><risdate>2006</risdate><volume>40</volume><issue>1</issue><spage>60</spage><epage>65</epage><pages>60-65</pages><issn>1046-2023</issn><eissn>1095-9130</eissn><abstract>Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. 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| ispartof | Methods (San Diego, Calif.), 2006-09, Vol.40 (1), p.60-65 |
| issn | 1046-2023 1095-9130 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7128828 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antibody Formation Chemistry, Pharmaceutical - methods Chimeric VLPs Dendritic Cells - immunology Immunity, Cellular Vaccine Viral Vaccines - administration & dosage Virosomes - immunology Virus-like particles |
| title | Virus-like particles: Passport to immune recognition |
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