Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives

An extended feature of the pharmacophore model of SARS-CoV NTPase/helicase was proposed which is constituted of a diketoacid core, a hydrophobic arylmethyl substituent, and a free catechol unit. Aryl diketoacids have been identified as the first SARS-CoV NTPase/helicase inhibitors with a distinct ph...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (16), p.4538-4541
Hauptverfasser:	Lee, Chaewoon, Lee, Jin Moo, Lee, Na-Ra, Kim, Dong-Eun, Jeong, Yong-Joo, Chong, Youhoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Catechols - chemistry Chromones - chemical synthesis Chromones - chemistry Chromones - pharmacology Dihydroxychromone DNA Helicases - antagonists & inhibitors DNA Helicases - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Medical sciences NTPase/helicase Pharmacology. Drug treatments Pharmacophore SARS (Severe Acute Respiratory Syndrome) SARS coronavirus SARS Virus - enzymology Structure-Activity Relationship
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