Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

An escalating pandemic by the novel SARS-CoV-2 virus is impacting global health and effective therapeutic options are urgently needed. We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evalu...

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Veröffentlicht in:	Antiviral research 2020-06, Vol.178, p.104786-104786, Article 104786
Hauptverfasser:	Choy, Ka-Tim, Wong, Alvina Yin-Lam, Kaewpreedee, Prathanporn, Sia, Sin Fun, Chen, Dongdong, Hui, Kenrie Pui Yan, Chu, Daniel Ka Wing, Chan, Michael Chi Wai, Cheung, Peter Pak-Hang, Huang, Xuhui, Peiris, Malik, Yen, Hui-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	ABSTRACT Adenosine Monophosphate - analogs & derivatives Alanine - analogs & derivatives Amides - pharmacology Animals Antimetabolites - pharmacology Antiviral Agents - pharmacology Betacoronavirus - drug effects Betacoronavirus - physiology Chlorocebus aethiops Coronavirus Infections - drug therapy Coronavirus Infections - virology COVID-19 Drug Combinations Emetine Emetine - pharmacology Epithelial Cells Homoharringtonine Homoharringtonine - pharmacology Humans Lopinavir Lopinavir - pharmacology Pandemics Pneumonia, Viral - drug therapy Pneumonia, Viral - virology Pyrazines - pharmacology Remdesivir Ribavirin - pharmacology Ritonavir SARS-CoV-2 Vero Cells Virus Replication - drug effects
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