G-Quadruplexes: More Than Just a Kink in Microbial Genomes

G-quadruplexes (G4s) are noncanonical nucleic acid secondary structures formed by guanine-rich DNA and RNA sequences. In this review we aim to provide an overview of the biological roles of G4s in microbial genomes with emphasis on recent discoveries. G4s are enriched and conserved in the regulatory...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2019-02, Vol.27 (2), p.148-163
Hauptverfasser:	Saranathan, Nandhini, Vivekanandan, Perumal
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigenic Variation - genetics bacteria Bacteria - genetics Base Sequence biological functions Carrier Proteins Deoxyribonucleic acid DNA Epstein-Barr virus Fungi Fungi - genetics G-quadruplexes G-Quadruplexes - drug effects G-Quadruplexes - radiation effects G4s Gene Expression Regulation Gene sequencing Genome, Microbial Genomes Guanine Hepatitis Hepatitis B Hepatitis C Herpesvirus 4, Human - genetics Humans microbes Microorganisms Nucleotide sequence Radiation Tolerance Recombination, Genetic Regulatory sequences Ribonucleic acid RNA RNA Editing Virion Virulence Virus Assembly Virus Latency - genetics Virus Replication - genetics Viruses Viruses - genetics
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