Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

A variety of benzophenone thiosemicarbazone analogs have been designed and prepared by chemical synthesis. A sub-set of these compounds demonstrated potent inhibition of cathepsin L with minimal inhibition of cathepsin B. A small library of 36 functionalized benzophenone thiosemicarbazone analogs ha...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2010-02, Vol.20 (4), p.1415-1419
Hauptverfasser: Kishore Kumar, G.D., Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Arispe, Wara M., MacDonough, Matthew T., Strecker, Tracy E., Chen, Shen-En, Siim, Bronwyn G., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
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Sprache:eng
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