Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
A variety of benzophenone thiosemicarbazone analogs have been designed and prepared by chemical synthesis. A sub-set of these compounds demonstrated potent inhibition of cathepsin L with minimal inhibition of cathepsin B. A small library of 36 functionalized benzophenone thiosemicarbazone analogs ha...
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2010-02, Vol.20 (4), p.1415-1419 |
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Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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