Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss
Purpose To study the contribution of embryo chromosomal abnormalities in primary and secondary recurrent pregnancy loss (RPL) and to analyze the recurrence of chromosomal constitution in miscarriages from the same couple. Methods Retrospective study of abortion karyotypes in RPL families based on th...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2020-03, Vol.37 (3), p.517-525 |
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| creator | Nikitina, T. V. Sazhenova, E. A. Zhigalina, D. I. Tolmacheva, E. N. Sukhanova, N. N. Lebedev, I. N. |
| description | Purpose
To study the contribution of embryo chromosomal abnormalities in primary and secondary recurrent pregnancy loss (RPL) and to analyze the recurrence of chromosomal constitution in miscarriages from the same couple.
Methods
Retrospective study of abortion karyotypes in RPL families based on the mother’s primary or secondary RPL status (563 embryo specimens, 335 samples from primary, and 228 samples from secondary RPL). RPL was defined as two or more consecutive miscarriages. One hundred eight cases of recurrent embryo/fetal loss in 51 families were analyzed to assess the probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in both previous and subsequent pregnancy loss. The karyotypes of abortions were established using standard cytogenetic analysis, as well as interphase fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH).
Results
The frequency of aberrations was 43.9% in abortions from primary RPL versus 52.6% in secondary RPL (
p
= 0.041). Women 35 years of age or older were the main contributors to this difference. The odds ratio of a subsequent abortion having the same karyotype pattern (normal or abnormal) as the previous one was 6.98 (
p
= 0.0013).
Conclusion
The frequency of abnormalities is higher in abortions from the secondary RPL versus primary RPL group, and this difference is due to the relative deficiency of miscarriages with abnormal karyotypes in older women with primary RPL. The probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in the previous and subsequent abortion is increased significantly compared with chance. |
| doi_str_mv | 10.1007/s10815-020-01703-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7125272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2350354597</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-793efab99af5e35279e3c01e6330c1e06ebde3ea2830f4d42f15f6ff1eeac7703</originalsourceid><addsrcrecordid>eNp9UU1v1DAQtRAVLW3_AAdkiQuX0LEdx8kFCVWloFbiAjcky-uMl1RZe7GTSvn3ne0u5ePAyWO_N2_m-TH2SsA7AWAuioBW6AokVCAMqGp5xk6ENqoySsFzqkG3FdRNe8xelnIHAF0r1Qt2rCSVUsoT9v3G5SVNyxY53rtxdtOQIk-BZ9yim7DnbpXy7rHwIfJtHjbUwF3seUGfYr-7ZfRzzhgnwnEdXfQLH1MpZ-wouLHg-eE8Zd8-Xn29_FTdfrn-fPnhtvK1qafKdAqDW3WdCxqVlqZD5UFgQy68QGhw1aNCJ1sFoe5rGYQOTQgC0XlDxk_Z-73udl5tsPe0SXajPSxrkxvs30gcfth1urdGSBonSeDtQSCnnzOWyW6G4nEcXcQ0FyuVBqVr3RmivvmHepfmHMkesVrdto0RO5bcs3ymf8gYnpYRYHfh2X14lsKzj-HZhZpe_2njqeVXWkRQe0IhKK4x_579H9kHkmiobA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2385886717</pqid></control><display><type>article</type><title>Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nikitina, T. V. ; Sazhenova, E. A. ; Zhigalina, D. I. ; Tolmacheva, E. N. ; Sukhanova, N. N. ; Lebedev, I. N.</creator><creatorcontrib>Nikitina, T. V. ; Sazhenova, E. A. ; Zhigalina, D. I. ; Tolmacheva, E. N. ; Sukhanova, N. N. ; Lebedev, I. N.</creatorcontrib><description>Purpose
To study the contribution of embryo chromosomal abnormalities in primary and secondary recurrent pregnancy loss (RPL) and to analyze the recurrence of chromosomal constitution in miscarriages from the same couple.
Methods
Retrospective study of abortion karyotypes in RPL families based on the mother’s primary or secondary RPL status (563 embryo specimens, 335 samples from primary, and 228 samples from secondary RPL). RPL was defined as two or more consecutive miscarriages. One hundred eight cases of recurrent embryo/fetal loss in 51 families were analyzed to assess the probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in both previous and subsequent pregnancy loss. The karyotypes of abortions were established using standard cytogenetic analysis, as well as interphase fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH).
Results
The frequency of aberrations was 43.9% in abortions from primary RPL versus 52.6% in secondary RPL (
p
= 0.041). Women 35 years of age or older were the main contributors to this difference. The odds ratio of a subsequent abortion having the same karyotype pattern (normal or abnormal) as the previous one was 6.98 (
p
= 0.0013).
Conclusion
The frequency of abnormalities is higher in abortions from the secondary RPL versus primary RPL group, and this difference is due to the relative deficiency of miscarriages with abnormal karyotypes in older women with primary RPL. The probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in the previous and subsequent abortion is increased significantly compared with chance.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-020-01703-y</identifier><identifier>PMID: 32009222</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abortion ; Abortion, Induced - methods ; Abortion, Spontaneous - diagnosis ; Abortion, Spontaneous - genetics ; Abortion, Spontaneous - pathology ; Adult ; Aged ; Chromosome Aberrations ; Comparative Genomic Hybridization ; Cytogenetic Analysis ; Cytogenetics ; Female ; Fetuses ; Fluorescence in situ hybridization ; Genetics ; Gynecology ; Human Genetics ; Humans ; In Situ Hybridization, Fluorescence ; Karyotype ; Karyotypes ; Karyotyping - methods ; Maternal Age ; Medicine ; Medicine & Public Health ; Miscarriage ; Pregnancy ; Reproductive Medicine</subject><ispartof>Journal of assisted reproduction and genetics, 2020-03, Vol.37 (3), p.517-525</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-793efab99af5e35279e3c01e6330c1e06ebde3ea2830f4d42f15f6ff1eeac7703</citedby><cites>FETCH-LOGICAL-c474t-793efab99af5e35279e3c01e6330c1e06ebde3ea2830f4d42f15f6ff1eeac7703</cites><orcidid>0000-0003-3875-3932 ; 0000-0002-4230-6855 ; 0000-0002-0482-8046 ; 0000-0003-2800-8875 ; 0000-0001-6427-3276</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125272/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125272/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32009222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nikitina, T. V.</creatorcontrib><creatorcontrib>Sazhenova, E. A.</creatorcontrib><creatorcontrib>Zhigalina, D. I.</creatorcontrib><creatorcontrib>Tolmacheva, E. N.</creatorcontrib><creatorcontrib>Sukhanova, N. N.</creatorcontrib><creatorcontrib>Lebedev, I. N.</creatorcontrib><title>Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
To study the contribution of embryo chromosomal abnormalities in primary and secondary recurrent pregnancy loss (RPL) and to analyze the recurrence of chromosomal constitution in miscarriages from the same couple.
Methods
Retrospective study of abortion karyotypes in RPL families based on the mother’s primary or secondary RPL status (563 embryo specimens, 335 samples from primary, and 228 samples from secondary RPL). RPL was defined as two or more consecutive miscarriages. One hundred eight cases of recurrent embryo/fetal loss in 51 families were analyzed to assess the probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in both previous and subsequent pregnancy loss. The karyotypes of abortions were established using standard cytogenetic analysis, as well as interphase fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH).
Results
The frequency of aberrations was 43.9% in abortions from primary RPL versus 52.6% in secondary RPL (
p
= 0.041). Women 35 years of age or older were the main contributors to this difference. The odds ratio of a subsequent abortion having the same karyotype pattern (normal or abnormal) as the previous one was 6.98 (
p
= 0.0013).
Conclusion
The frequency of abnormalities is higher in abortions from the secondary RPL versus primary RPL group, and this difference is due to the relative deficiency of miscarriages with abnormal karyotypes in older women with primary RPL. The probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in the previous and subsequent abortion is increased significantly compared with chance.</description><subject>Abortion</subject><subject>Abortion, Induced - methods</subject><subject>Abortion, Spontaneous - diagnosis</subject><subject>Abortion, Spontaneous - genetics</subject><subject>Abortion, Spontaneous - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Chromosome Aberrations</subject><subject>Comparative Genomic Hybridization</subject><subject>Cytogenetic Analysis</subject><subject>Cytogenetics</subject><subject>Female</subject><subject>Fetuses</subject><subject>Fluorescence in situ hybridization</subject><subject>Genetics</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Karyotype</subject><subject>Karyotypes</subject><subject>Karyotyping - methods</subject><subject>Maternal Age</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscarriage</subject><subject>Pregnancy</subject><subject>Reproductive Medicine</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UU1v1DAQtRAVLW3_AAdkiQuX0LEdx8kFCVWloFbiAjcky-uMl1RZe7GTSvn3ne0u5ePAyWO_N2_m-TH2SsA7AWAuioBW6AokVCAMqGp5xk6ENqoySsFzqkG3FdRNe8xelnIHAF0r1Qt2rCSVUsoT9v3G5SVNyxY53rtxdtOQIk-BZ9yim7DnbpXy7rHwIfJtHjbUwF3seUGfYr-7ZfRzzhgnwnEdXfQLH1MpZ-wouLHg-eE8Zd8-Xn29_FTdfrn-fPnhtvK1qafKdAqDW3WdCxqVlqZD5UFgQy68QGhw1aNCJ1sFoe5rGYQOTQgC0XlDxk_Z-73udl5tsPe0SXajPSxrkxvs30gcfth1urdGSBonSeDtQSCnnzOWyW6G4nEcXcQ0FyuVBqVr3RmivvmHepfmHMkesVrdto0RO5bcs3ymf8gYnpYRYHfh2X14lsKzj-HZhZpe_2njqeVXWkRQe0IhKK4x_579H9kHkmiobA</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Nikitina, T. V.</creator><creator>Sazhenova, E. A.</creator><creator>Zhigalina, D. I.</creator><creator>Tolmacheva, E. N.</creator><creator>Sukhanova, N. N.</creator><creator>Lebedev, I. N.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3875-3932</orcidid><orcidid>https://orcid.org/0000-0002-4230-6855</orcidid><orcidid>https://orcid.org/0000-0002-0482-8046</orcidid><orcidid>https://orcid.org/0000-0003-2800-8875</orcidid><orcidid>https://orcid.org/0000-0001-6427-3276</orcidid></search><sort><creationdate>20200301</creationdate><title>Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss</title><author>Nikitina, T. V. ; Sazhenova, E. A. ; Zhigalina, D. I. ; Tolmacheva, E. N. ; Sukhanova, N. N. ; Lebedev, I. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-793efab99af5e35279e3c01e6330c1e06ebde3ea2830f4d42f15f6ff1eeac7703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abortion</topic><topic>Abortion, Induced - methods</topic><topic>Abortion, Spontaneous - diagnosis</topic><topic>Abortion, Spontaneous - genetics</topic><topic>Abortion, Spontaneous - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Chromosome Aberrations</topic><topic>Comparative Genomic Hybridization</topic><topic>Cytogenetic Analysis</topic><topic>Cytogenetics</topic><topic>Female</topic><topic>Fetuses</topic><topic>Fluorescence in situ hybridization</topic><topic>Genetics</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Karyotype</topic><topic>Karyotypes</topic><topic>Karyotyping - methods</topic><topic>Maternal Age</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscarriage</topic><topic>Pregnancy</topic><topic>Reproductive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nikitina, T. V.</creatorcontrib><creatorcontrib>Sazhenova, E. A.</creatorcontrib><creatorcontrib>Zhigalina, D. I.</creatorcontrib><creatorcontrib>Tolmacheva, E. N.</creatorcontrib><creatorcontrib>Sukhanova, N. N.</creatorcontrib><creatorcontrib>Lebedev, I. N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nikitina, T. V.</au><au>Sazhenova, E. A.</au><au>Zhigalina, D. I.</au><au>Tolmacheva, E. N.</au><au>Sukhanova, N. N.</au><au>Lebedev, I. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>37</volume><issue>3</issue><spage>517</spage><epage>525</epage><pages>517-525</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
To study the contribution of embryo chromosomal abnormalities in primary and secondary recurrent pregnancy loss (RPL) and to analyze the recurrence of chromosomal constitution in miscarriages from the same couple.
Methods
Retrospective study of abortion karyotypes in RPL families based on the mother’s primary or secondary RPL status (563 embryo specimens, 335 samples from primary, and 228 samples from secondary RPL). RPL was defined as two or more consecutive miscarriages. One hundred eight cases of recurrent embryo/fetal loss in 51 families were analyzed to assess the probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in both previous and subsequent pregnancy loss. The karyotypes of abortions were established using standard cytogenetic analysis, as well as interphase fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH).
Results
The frequency of aberrations was 43.9% in abortions from primary RPL versus 52.6% in secondary RPL (
p
= 0.041). Women 35 years of age or older were the main contributors to this difference. The odds ratio of a subsequent abortion having the same karyotype pattern (normal or abnormal) as the previous one was 6.98 (
p
= 0.0013).
Conclusion
The frequency of abnormalities is higher in abortions from the secondary RPL versus primary RPL group, and this difference is due to the relative deficiency of miscarriages with abnormal karyotypes in older women with primary RPL. The probability of having the same karyotype pattern (recurrent normal or recurrent abnormal) in the previous and subsequent abortion is increased significantly compared with chance.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32009222</pmid><doi>10.1007/s10815-020-01703-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3875-3932</orcidid><orcidid>https://orcid.org/0000-0002-4230-6855</orcidid><orcidid>https://orcid.org/0000-0002-0482-8046</orcidid><orcidid>https://orcid.org/0000-0003-2800-8875</orcidid><orcidid>https://orcid.org/0000-0001-6427-3276</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Abortion Abortion, Induced - methods Abortion, Spontaneous - diagnosis Abortion, Spontaneous - genetics Abortion, Spontaneous - pathology Adult Aged Chromosome Aberrations Comparative Genomic Hybridization Cytogenetic Analysis Cytogenetics Female Fetuses Fluorescence in situ hybridization Genetics Gynecology Human Genetics Humans In Situ Hybridization, Fluorescence Karyotype Karyotypes Karyotyping - methods Maternal Age Medicine Medicine & Public Health Miscarriage Pregnancy Reproductive Medicine |
| title | Karyotype evaluation of repeated abortions in primary and secondary recurrent pregnancy loss |
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