The reproducibility of trophectoderm biopsies in euploid, aneuploid, and mosaic embryos using independently verified next-generation sequencing (NGS): a pilot study

Purpose To assess the accuracy and reliability of comprehensive chromosome screening by next-generation sequencing (NGS) of human trophectoderm (TE) biopsy specimens. Methods The reliability and accuracy of diagnoses made by preimplantation genetic testing for aneuploidy (PGT-A) from TE biopsy were...

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Veröffentlicht in:	Journal of assisted reproduction and genetics 2020-03, Vol.37 (3), p.559-571
Hauptverfasser:	Sachdev, Nidhee M., McCulloh, David H., Kramer, Yael, Keefe, David, Grifo, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Adult Aneuploidy Biopsy Blastocyst - metabolism Blastocyst Inner Cell Mass - metabolism Blastocyst Inner Cell Mass - pathology Blastocysts Chromosomes Chromosomes - genetics Copy number Disjunction Ectoderm - growth & development Ectoderm - metabolism Embryos Female Fetuses Genetic screening Genetic Testing Genetics Genomes Gynecology High-Throughput Nucleotide Sequencing - methods Human Genetics Humans Medicine Medicine & Public Health Mosaicism Next-generation sequencing Pilot Projects Pregnancy Preimplantation Diagnosis Reproducibility Reproductive Medicine Trophectoderm
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