Carcinoid Syndrome: A Review
Carcinoid syndrome (CS) is a paraneoplastic syndrome caused by the release of serotonin and other substances from well-differentiated neuroendocrine tumors (NETs). The hallmark symptoms of carcinoid syndrome are flushing and diarrhea; atypical signs and symptoms can include wheezing, abdominal pain,...
Gespeichert in:
| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2020-03, Vol.12 (3), p.e7186-e7186 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e7186 |
|---|---|
| container_issue | 3 |
| container_start_page | e7186 |
| container_title | Curēus (Palo Alto, CA) |
| container_volume | 12 |
| creator | Gade, Ajay K Olariu, Eva Douthit, Nathan T |
| description | Carcinoid syndrome (CS) is a paraneoplastic syndrome caused by the release of serotonin and other substances from well-differentiated neuroendocrine tumors (NETs). The hallmark symptoms of carcinoid syndrome are flushing and diarrhea; atypical signs and symptoms can include wheezing, abdominal pain, valvular heart disease, telangiectasias, pellagra, and the complications of mesenteric fibrosis, including ureteral obstruction, bowel obstruction, and bowel ischemia. These symptoms are mediated by the release of serotonin (5-HT), histamine, kallikrein, prostaglandins, and tachykinins. The diagnosis of CS requires these symptoms and corresponding elevations in lab tests. Treatment options include surgery and medical management with somatostatin analogs. |
| doi_str_mv | 10.7759/cureus.7186 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7124884</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2396566208</sourcerecordid><originalsourceid>FETCH-LOGICAL-c339t-a11fdbadc5942080454fc230ff9513263a82836f783fb1a448692eb69f689c113</originalsourceid><addsrcrecordid>eNpdkEtLAzEURoMottSu3IoU3AgyNe-HC6EUX1AQfKxDJpPolOmkJp1K_71TWkt1dS_cw8d3DwCnCA6FYOraNtE1aSiQ5AegixGXmUSSHu7tHdBPaQohRFBgKOAx6BCMmRCYdcHZ2ERb1qEsBq-ruohh5m4Go8GLW5bu-wQceVMl19_OHni_v3sbP2aT54en8WiSWULUIjMI-SI3hWWKYighZdRbTKD3iiGCOTESS8K9kMTnyFAqucIu58pzqSxCpAduN7nzJp-5wrp6EU2l57GcmbjSwZT676UuP_VHWGqBMJWStgGX24AYvhqXFnpWJuuqytQuNEljIgVnQnHRohf_0GloYt2-11KKM87bF1rqakPZGFKKzu_KIKjX4vVGvF6Lb-nz_f479lcz-QF3pnzy</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2396566208</pqid></control><display><type>article</type><title>Carcinoid Syndrome: A Review</title><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Gade, Ajay K ; Olariu, Eva ; Douthit, Nathan T</creator><creatorcontrib>Gade, Ajay K ; Olariu, Eva ; Douthit, Nathan T</creatorcontrib><description>Carcinoid syndrome (CS) is a paraneoplastic syndrome caused by the release of serotonin and other substances from well-differentiated neuroendocrine tumors (NETs). The hallmark symptoms of carcinoid syndrome are flushing and diarrhea; atypical signs and symptoms can include wheezing, abdominal pain, valvular heart disease, telangiectasias, pellagra, and the complications of mesenteric fibrosis, including ureteral obstruction, bowel obstruction, and bowel ischemia. These symptoms are mediated by the release of serotonin (5-HT), histamine, kallikrein, prostaglandins, and tachykinins. The diagnosis of CS requires these symptoms and corresponding elevations in lab tests. Treatment options include surgery and medical management with somatostatin analogs.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.7186</identifier><identifier>PMID: 32257725</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Cardiovascular disease ; Diarrhea ; Gastroenterology ; Heart ; Histopathology ; Hormones ; Indium ; Ischemia ; Laboratories ; Liver ; Lungs ; Neuroendocrine tumors ; Oncology ; Patients ; Peptides ; Plasma ; Serotonin ; Urine ; X-rays</subject><ispartof>Curēus (Palo Alto, CA), 2020-03, Vol.12 (3), p.e7186-e7186</ispartof><rights>Copyright © 2020, Gade et al.</rights><rights>Copyright © 2020, Gade et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2020, Gade et al. 2020 Gade et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-a11fdbadc5942080454fc230ff9513263a82836f783fb1a448692eb69f689c113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124884/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124884/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32257725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gade, Ajay K</creatorcontrib><creatorcontrib>Olariu, Eva</creatorcontrib><creatorcontrib>Douthit, Nathan T</creatorcontrib><title>Carcinoid Syndrome: A Review</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Carcinoid syndrome (CS) is a paraneoplastic syndrome caused by the release of serotonin and other substances from well-differentiated neuroendocrine tumors (NETs). The hallmark symptoms of carcinoid syndrome are flushing and diarrhea; atypical signs and symptoms can include wheezing, abdominal pain, valvular heart disease, telangiectasias, pellagra, and the complications of mesenteric fibrosis, including ureteral obstruction, bowel obstruction, and bowel ischemia. These symptoms are mediated by the release of serotonin (5-HT), histamine, kallikrein, prostaglandins, and tachykinins. The diagnosis of CS requires these symptoms and corresponding elevations in lab tests. Treatment options include surgery and medical management with somatostatin analogs.</description><subject>Cardiovascular disease</subject><subject>Diarrhea</subject><subject>Gastroenterology</subject><subject>Heart</subject><subject>Histopathology</subject><subject>Hormones</subject><subject>Indium</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Lungs</subject><subject>Neuroendocrine tumors</subject><subject>Oncology</subject><subject>Patients</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Serotonin</subject><subject>Urine</subject><subject>X-rays</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkEtLAzEURoMottSu3IoU3AgyNe-HC6EUX1AQfKxDJpPolOmkJp1K_71TWkt1dS_cw8d3DwCnCA6FYOraNtE1aSiQ5AegixGXmUSSHu7tHdBPaQohRFBgKOAx6BCMmRCYdcHZ2ERb1qEsBq-ruohh5m4Go8GLW5bu-wQceVMl19_OHni_v3sbP2aT54en8WiSWULUIjMI-SI3hWWKYighZdRbTKD3iiGCOTESS8K9kMTnyFAqucIu58pzqSxCpAduN7nzJp-5wrp6EU2l57GcmbjSwZT676UuP_VHWGqBMJWStgGX24AYvhqXFnpWJuuqytQuNEljIgVnQnHRohf_0GloYt2-11KKM87bF1rqakPZGFKKzu_KIKjX4vVGvF6Lb-nz_f479lcz-QF3pnzy</recordid><startdate>20200305</startdate><enddate>20200305</enddate><creator>Gade, Ajay K</creator><creator>Olariu, Eva</creator><creator>Douthit, Nathan T</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200305</creationdate><title>Carcinoid Syndrome: A Review</title><author>Gade, Ajay K ; Olariu, Eva ; Douthit, Nathan T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-a11fdbadc5942080454fc230ff9513263a82836f783fb1a448692eb69f689c113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cardiovascular disease</topic><topic>Diarrhea</topic><topic>Gastroenterology</topic><topic>Heart</topic><topic>Histopathology</topic><topic>Hormones</topic><topic>Indium</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Liver</topic><topic>Lungs</topic><topic>Neuroendocrine tumors</topic><topic>Oncology</topic><topic>Patients</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Serotonin</topic><topic>Urine</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gade, Ajay K</creatorcontrib><creatorcontrib>Olariu, Eva</creatorcontrib><creatorcontrib>Douthit, Nathan T</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gade, Ajay K</au><au>Olariu, Eva</au><au>Douthit, Nathan T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinoid Syndrome: A Review</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2020-03-05</date><risdate>2020</risdate><volume>12</volume><issue>3</issue><spage>e7186</spage><epage>e7186</epage><pages>e7186-e7186</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Carcinoid syndrome (CS) is a paraneoplastic syndrome caused by the release of serotonin and other substances from well-differentiated neuroendocrine tumors (NETs). The hallmark symptoms of carcinoid syndrome are flushing and diarrhea; atypical signs and symptoms can include wheezing, abdominal pain, valvular heart disease, telangiectasias, pellagra, and the complications of mesenteric fibrosis, including ureteral obstruction, bowel obstruction, and bowel ischemia. These symptoms are mediated by the release of serotonin (5-HT), histamine, kallikrein, prostaglandins, and tachykinins. The diagnosis of CS requires these symptoms and corresponding elevations in lab tests. Treatment options include surgery and medical management with somatostatin analogs.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>32257725</pmid><doi>10.7759/cureus.7186</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2168-8184 |
| ispartof | Curēus (Palo Alto, CA), 2020-03, Vol.12 (3), p.e7186-e7186 |
| issn | 2168-8184 2168-8184 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7124884 |
| source | PubMed Central Open Access; PubMed Central |
| subjects | Cardiovascular disease Diarrhea Gastroenterology Heart Histopathology Hormones Indium Ischemia Laboratories Liver Lungs Neuroendocrine tumors Oncology Patients Peptides Plasma Serotonin Urine X-rays |
| title | Carcinoid Syndrome: A Review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T16%3A39%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carcinoid%20Syndrome:%20A%20Review&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Gade,%20Ajay%20K&rft.date=2020-03-05&rft.volume=12&rft.issue=3&rft.spage=e7186&rft.epage=e7186&rft.pages=e7186-e7186&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.7186&rft_dat=%3Cproquest_pubme%3E2396566208%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2396566208&rft_id=info:pmid/32257725&rfr_iscdi=true |