Effect of experimental infection of cattle with bovine herpesvirus-1 (BHV-1) on the ex vivo interaction of bovine leukocytes with Mannheimia ( Pasteurella) haemolytica leukotoxin

Mannheimia ( Pasteurella) haemolytica A1 produces an extracellular leukotoxin (LKT) that is reported to bind the β 2-integrin CD11a/CD18 (LEA-1) on ruminant leukocytes. LKT binding induces activation, and subsequent cytolysis, of these cells. It is well known that active viral infection greatly incr...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2002-01, Vol.84 (1), p.97-110
Hauptverfasser:	Leite, F., Sylte, M.J., O’Brien, S., Schultz, R., Peek, S., van Reeth, K., Czuprynski, C.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BHV-1 Bovine Bovine herpesvirus 1 Cattle CD11a antigen CD18 antigen CD18 Antigens - analysis Exotoxins - metabolism Exotoxins - toxicity Herpesviridae Infections - immunology Herpesvirus 1, Bovine Leukocytes Leukocytes - drug effects Leukocytes - immunology Leukotoxin leukotoxins Lymphocyte Function-Associated Antigen-1 - analysis Mannheimia haemolytica Mannheimia haemolytica - pathogenicity Pasteurella haemolytica Pasteurellosis
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