ACE2: from vasopeptidase to SARS virus receptor
The zinc metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the only known human homologue of the key regulator of blood pressure angiotensin-converting enzyme (ACE). Since its discovery in 2000, ACE2 has been implicated in heart function, hypertension and diabetes, with its effects being me...
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| Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2004-06, Vol.25 (6), p.291-294 |
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| creator | Turner, Anthony J Hiscox, Julian A Hooper, Nigel M |
| description | The zinc metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the only known human homologue of the key regulator of blood pressure angiotensin-converting enzyme (ACE). Since its discovery in 2000, ACE2 has been implicated in heart function, hypertension and diabetes, with its effects being mediated, in part, through its ability to convert angiotensin II to angiotensin-(1–7). Unexpectedly, ACE2 also serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus and the enzyme is therefore a prime target for pharmacological intervention on several disease fronts. |
| doi_str_mv | 10.1016/j.tips.2004.04.001 |
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| fulltext | fulltext |
| identifier | ISSN: 0165-6147 |
| ispartof | Trends in pharmacological sciences (Regular ed.), 2004-06, Vol.25 (6), p.291-294 |
| issn | 0165-6147 1873-3735 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Blood Vessels - metabolism Blood Vessels - physiology Humans Isoenzymes - genetics Isoenzymes - physiology Peptide Hormones - metabolism Peptide Hormones - physiology Peptide Hydrolases - physiology Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - physiology Receptors, Virus - genetics SARS Virus - genetics |
| title | ACE2: from vasopeptidase to SARS virus receptor |
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