BAG3 down-modulation sensitizes HPV18+ HeLa cells to PEITC-induced apoptosis and restores p53

Highlights • BAG3 down-modulation by siRNA technology restored p53. • Reduced BAG3 expression sensitized HeLa but not C33A (HPV-negative) cells to PEITC. • Reduced BAG3 expression was associated with a decrease of E6 viral protein levels.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-11, Vol.354 (2), p.263-271
Hauptverfasser:	Cotugno, Roberta, Basile, Anna, Romano, Elena, Gallotta, Dario, Belisario, Maria Antonietta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism BAG3 Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cervical cancer DNA-Binding Proteins - metabolism Down-Regulation Experiments Female Gene expression HeLa Cells Hematology, Oncology and Palliative Medicine HPV18 Human papillomavirus Human papillomavirus 18 Humans Isothiocyanates - pharmacology Oncogene Proteins, Viral - metabolism Original p53 PEITC Proteins RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Studies Transfection Tumor Suppressor Protein p53 - metabolism Ubiquitin-Protein Ligases - metabolism Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology Viral infections
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