Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease

The melanocyte-inducing transcription factor (MITF)-low melanoma transcriptional signature is predictive of poor outcomes for patients, but little is known about its biological significance, and animal models are lacking. Here, we used zebrafish genetic models with low activity of Mitfa (MITF-low) a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-11, Vol.79 (22), p.5769-5784
Hauptverfasser:	Travnickova, Jana, Wojciechowska, Sonia, Khamseh, Ava, Gautier, Philippe, Brown, Daniel V, Lefevre, Thomas, Brombin, Alessandro, Ewing, Ailith, Capper, Amy, Spitzer, Michaela, Dilshat, Ramile, Semple, Colin A, Mathers, Marie E, Lister, James A, Steingrimsson, Eiríkur, Voet, Thierry, Ponting, Chris P, Patton, E Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Resistance - genetics Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Melanocytes - pathology Melanoma - genetics Melanoma - pathology Microphthalmia-Associated Transcription Factor - genetics Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm, Residual - genetics Neoplasm, Residual - pathology Neural Crest - pathology Proto-Oncogene Proteins B-raf - genetics Stem Cells - pathology Transcription, Genetic - genetics Zebrafish - genetics
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