Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

β-Arrestins (βarrs) critically regulate G-protein-coupled receptor (GPCR) signaling and trafficking. βarrs have two isoforms, βarr1 and βarr2. Receptor phosphorylation is a key determinant for the binding of βarrs, and understanding the intricate details of receptor-βarr interaction is the next fron...

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Veröffentlicht in:	Structure (London) 2020-09, Vol.28 (9), p.1014-1023.e4
Hauptverfasser:	Min, Kyungjin, Yoon, Hye-Jin, Park, Ji Young, Baidya, Mithu, Dwivedi-Agnihotri, Hemlata, Maharana, Jagannath, Chaturvedi, Madhu, Chung, Ka Young, Shukla, Arun K., Lee, Hyung Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Arrestin 2 - agonists beta-Arrestin 2 - chemistry beta-Arrestin 2 - genetics beta-Arrestin 2 - metabolism biased agonism Calorimetry Crystallography, X-Ray CXCR7 G-protein-coupled receptors (GPCRs) HEK293 Cells Humans Phosphopeptides - chemistry Phosphopeptides - metabolism Phosphorylation Protein Domains Protein Transport - drug effects Receptors, CXCR - chemistry Receptors, CXCR - metabolism synthetic antibody fragments β-arrestins
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