Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating that the rest of the hippocampus (CA1–CA3) can operate autonomously under certain conditions. An extensive body of theoretica...
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| Veröffentlicht in: | Nature reviews. Neuroscience 2020-03, Vol.21 (3), p.153-168 |
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| description | The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating that the rest of the hippocampus (CA1–CA3) can operate autonomously under certain conditions. An extensive body of theoretical work has proposed how the architectural elements and various cell types of the DG may underlie its function in cognition. Recent studies recorded and manipulated the activity of different neuron types in the DG during memory tasks and have provided exciting new insights into the mechanisms of DG computational processes, particularly for the encoding, retrieval and discrimination of similar memories. Here, we review these DG-dependent mnemonic functions in light of the new findings and explore mechanistic links between the cellular and network properties of, and the computations performed by, the DG.
The dentate gyrus has an important role in memory formation in the hippocampus. In this Review, Thomas Hainmueller and Marlene Bartos examine the cells and circuits of the dentate gyrus, and discuss the evidence indicating that this brain region has multiple mnemonic functions. |
| doi_str_mv | 10.1038/s41583-019-0260-z |
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The dentate gyrus has an important role in memory formation in the hippocampus. 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Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hainmueller, Thomas</au><au>Bartos, Marlene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories</atitle><jtitle>Nature reviews. Neuroscience</jtitle><stitle>Nat Rev Neurosci</stitle><addtitle>Nat Rev Neurosci</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>21</volume><issue>3</issue><spage>153</spage><epage>168</epage><pages>153-168</pages><issn>1471-003X</issn><eissn>1471-0048</eissn><eissn>1469-3178</eissn><abstract>The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating that the rest of the hippocampus (CA1–CA3) can operate autonomously under certain conditions. 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| subjects | 631/378/1595 631/378/1595/1554 631/378/3920 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Circuits Cognition Computational neuroscience Dentate gyrus Dentate Gyrus - physiology Discrimination Learning - physiology Entorhinal Cortex - physiology Episodic memory Hippocampus Humans Memory Memory Consolidation - physiology Memory, Episodic Mental Recall - physiology Models, Neurological Neural circuitry Neurobiology Neurogenesis Neurological research Neurons - physiology Neurosciences Observations Physiological aspects Recall Review Article Semantics |
| title | Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories |
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