Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses

► We investigated the antiviral activities of mucroporin and optimized mucroporin-M1. ► Mucroporin and mucroporin-M1 were scorpion venom-derived host defense peptides. ► Mucroporin-M1 but not mucroporin had antiviral activities against tested viruses. ► The tested viruses were measles, SARS-CoV and...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2011-07, Vol.32 (7), p.1518-1525
Hauptverfasser:	Li, Qiaoli, Zhao, Zhenhuan, Zhou, Dihan, Chen, Yaoqing, Hong, Wei, Cao, Luyang, Yang, Jingyi, Zhang, Yan, Shi, Wei, Cao, Zhijian, Wu, Yingliang, Yan, Huimin, Li, Wenxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals antibiotic resistance Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - pharmacology Antiviral antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use antiviral properties Bacteria Biological and medical sciences Cell Line Dogs Drug Design Fundamental and applied biological sciences. Psychology Gram-positive bacteria H5N1 Human viral diseases Humans Infectious diseases Influenza Influenza A virus Influenza A Virus, H5N1 Subtype - drug effects Influenza A Virus, H5N1 Subtype - physiology Influenza, Human - drug therapy Influenza, Human - pathology Influenza, Human - virology Inhibitory Concentration 50 Measles Measles - drug therapy Measles - pathology Measles - virology Measles virus Medical sciences Molecular Sequence Data Morbillivirus - drug effects Morbillivirus - physiology Mucroporin-M1 Outbreaks Pandemics - prevention & control pathogenicity Pathogens Peptides Protein Binding Ribonucleic acids RNA SARS coronavirus SARS Virus - drug effects SARS Virus - physiology SARS-CoV Scorpion venom Scorpion Venoms - chemistry Scorpion Venoms - genetics Scorpion Venoms - metabolism Scorpiones Scorpions - chemistry Scorpions - genetics Scorpions - metabolism Severe Acute Respiratory Syndrome - drug therapy Severe Acute Respiratory Syndrome - pathology Severe Acute Respiratory Syndrome - virology Severe acute respiratory syndrome coronavirus vaccination venoms Vertebrates: endocrinology Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Viral Envelope Proteins - metabolism Virus Internalization - drug effects Virus Replication - drug effects Viruses
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