Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in the spike 2 domain and the nucleocapsid protein of feline infectious peritonitis virus

The antibody-dependent enhancement (ADE) of feline infectious peritonitis virus (FIPV) infection has been recognized in experimentally infected cats, and cellular immunity is considered to play an important role in preventing the onset of feline infectious peritonitis (FIP). In the present study, we...

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Veröffentlicht in:	Vaccine 2011-02, Vol.29 (9), p.1791-1800
Hauptverfasser:	Satoh, Ryoichi, Furukawa, Tomoko, Kotake, Masako, Takano, Tomomi, Motokawa, Kenji, Gemma, Tsuyoshi, Watanabe, Rie, Arai, Setsuo, Hohdatsu, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amino Acid Sequence Amino acids Animals Antibodies, Viral - immunology Antibodies, Viral - metabolism Applied microbiology Binding Sites, Antibody Biological and medical sciences Cats CD4-positive T-lymphocytes cell-mediated immunity Coronavirus Coronavirus, Feline - immunology Coronavirus, Feline - metabolism enzyme-linked immunosorbent assay epitopes Epitopes - immunology Epitopes - metabolism Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Feline coronavirus feline infectious peritonitis Feline Infectious Peritonitis - immunology Feline Infectious Peritonitis - metabolism Feline infectious peritonitis virus FIP Fundamental and applied biological sciences. Psychology Genetic Testing - methods immune response Immunodominant Epitopes - immunology Immunodominant Epitopes - metabolism Infections interferons Linear immunodominant antibody-binding epitope Microbiology Miscellaneous Molecular Sequence Data nucleocapsid proteins Nucleocapsid Proteins - immunology Nucleocapsid Proteins - metabolism Peptides Protein Structure, Tertiary Proteins screening Th1 Cells - immunology Th1 Cells - metabolism Th1 epitope vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Virology
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