The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection

Abstract The persistent public health threat of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective MERS-CoV vaccine. Previous studies have focused mainly on the receptor-binding domain (RBD) on the spike protein of MERS-CoV. Herein, we inv...

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Veröffentlicht in:	Vaccine 2017-01, Vol.35 (1), p.10-18
Hauptverfasser:	Jiaming, Lan, Yanfeng, Yao, Yao, Deng, Yawei, Hu, Linlin, Bao, Baoying, Huang, Jinghua, Yan, Gao, George F, Chuan, Qin, Wenjie, Tan
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Aluminum Animal model Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens Coronaviridae Coronavirus Infections - prevention & control Disease Models, Animal Enzymes Female Health risks Immune response Immunization Immunoassay Immunogenicity Immunoglobulin G - blood Immunoglobulins Infections Laboratory animals Lung - pathology MERS-CoV Mice Mice, Inbred BALB C Middle East Respiratory Syndrome Coronavirus - genetics Middle East Respiratory Syndrome Coronavirus - immunology NTD Proteins Public health R&D RBD Research & development Respiratory diseases Rodents Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Studies T-Lymphocytes - immunology Vaccine Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology
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