Synthesis and biological evaluation of 2-oxonicotinonitriles and 2-oxonicotinonitrile based nucleoside analogues

Drug resistance and emergence of new pathogens highlight the need for developing new therapeutic agents. We focused on 2-oxonicotinonitrile (2-ONN) as derivative of the natural product 2-pyridinone.112-ONN: 2-oxonicotinonitrile. Herein, we describe the synthesis of 2-ONNs bearing two aryl groups, wh...

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Veröffentlicht in:	European journal of medicinal chemistry 2014-03, Vol.74, p.388-397
Hauptverfasser:	Abou-Elkhair, Reham A.I., Moustafa, Ahmed H., Haikal, Abdelfattah Z., Ibraheem, Ahmed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Oxonicotinonitrile 2-Pyridinone Antimicrobial Antiviral Bacteria - drug effects Glycosylation Microbial Sensitivity Tests Nitriles - chemical synthesis Nitriles - pharmacology Nucleoside analogues Original Viruses - drug effects
Online-Zugang:	Volltext
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