The role of granulocyte colony‑stimulating factor in breast cancer development: A review
Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neu...
Gespeichert in:
| Veröffentlicht in: | Molecular medicine reports 2020-05, Vol.21 (5), p.2019-2029 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2029 |
|---|---|
| container_issue | 5 |
| container_start_page | 2019 |
| container_title | Molecular medicine reports |
| container_volume | 21 |
| creator | Liu, Li Liu, Yangyang Yan, Xiaohua Zhou, Chong Xiong, Xiangyang |
| description | Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G‑CSF plays an important role in cancer progression. G‑CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G‑CSF has an adverse effect. The current review provides an overview of G‑CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy. |
| doi_str_mv | 10.3892/mmr.2020.11017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7115204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2387257701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-7ea531953cc2b55fe4ab5a292def85780fc273761115058f38140f6b9f524e753</originalsourceid><addsrcrecordid>eNpVkctOwzAQRS0EouWxZYkssU7xI44dFkhVxUuqxKZs2FiOO25TJXFxkqLu-AV-kS8hpaWC1Yw0d85czUXogpIBVym7LsswYISRAaWEygPUpzKlESckPtz1LE1lD53U9YKQRDCRHqMeZ1QlMpF99DqZAw6-AOwdngVTtYW36waw9YWv1l8fn3WTl21hmryaYWds4wPOK5wFMHWDraksBDyFFRR-WULV3OAhDrDK4f0MHTlT1HC-q6fo5f5uMnqMxs8PT6PhOLIxVU0kwQhOU8GtZZkQDmKTCcNSNgWnhFTEWSa5TCilggjluKIxcUmWOsFikIKfotstd9lmJUxtZyKYQi9DXpqw1t7k-v-kyud65ldadkRG4g5wtQME_9ZC3eiFb0PVedaMK8mElIR2qsFWZYOv6wBuf4ESvclCd1noTRb6J4tu4fKvr7389_n8G6jxh0Y</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2387257701</pqid></control><display><type>article</type><title>The role of granulocyte colony‑stimulating factor in breast cancer development: A review</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Liu, Li ; Liu, Yangyang ; Yan, Xiaohua ; Zhou, Chong ; Xiong, Xiangyang</creator><creatorcontrib>Liu, Li ; Liu, Yangyang ; Yan, Xiaohua ; Zhou, Chong ; Xiong, Xiangyang</creatorcontrib><description>Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G‑CSF plays an important role in cancer progression. G‑CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G‑CSF has an adverse effect. The current review provides an overview of G‑CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2020.11017</identifier><identifier>PMID: 32186767</identifier><language>eng</language><publisher>Greece: Spandidos Publications UK Ltd</publisher><subject>Amino acids ; Animals ; Binding sites ; Bladder cancer ; Blood & organ donations ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Carcinogenesis - genetics ; Carcinogenesis - metabolism ; Cell adhesion & migration ; Cell growth ; Chemical bonds ; Chemotherapy ; Colonies ; Colony-stimulating factor ; Colorectal carcinoma ; Cytokines ; Disease Progression ; Female ; Gastric cancer ; Gene expression ; Gene Expression Regulation, Neoplastic ; Glioma ; Granulocyte colony-stimulating factor ; Granulocyte Colony-Stimulating Factor - genetics ; Granulocyte Colony-Stimulating Factor - physiology ; Granulocytes ; Hematopoietic stem cells ; Humans ; Invasiveness ; Kinases ; Leukocytes (granulocytic) ; Lung cancer ; Lung Neoplasms ; Medical prognosis ; Metastasis ; Neutropenia ; Neutropenia - metabolism ; Neutrophils ; Peripheral blood ; Phosphorylation ; Proteins ; Receptors, Granulocyte Colony-Stimulating Factor - metabolism ; Recombinant Proteins ; Stem cells ; Transcription factors ; Tumor Microenvironment ; Tumor necrosis factor-TNF ; Urinary Bladder Neoplasms</subject><ispartof>Molecular medicine reports, 2020-05, Vol.21 (5), p.2019-2029</ispartof><rights>Copyright Spandidos Publications UK Ltd. 2020</rights><rights>Copyright: © Liu et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-7ea531953cc2b55fe4ab5a292def85780fc273761115058f38140f6b9f524e753</citedby><cites>FETCH-LOGICAL-c418t-7ea531953cc2b55fe4ab5a292def85780fc273761115058f38140f6b9f524e753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32186767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Liu, Yangyang</creatorcontrib><creatorcontrib>Yan, Xiaohua</creatorcontrib><creatorcontrib>Zhou, Chong</creatorcontrib><creatorcontrib>Xiong, Xiangyang</creatorcontrib><title>The role of granulocyte colony‑stimulating factor in breast cancer development: A review</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G‑CSF plays an important role in cancer progression. G‑CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G‑CSF has an adverse effect. The current review provides an overview of G‑CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Bladder cancer</subject><subject>Blood & organ donations</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - metabolism</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Chemical bonds</subject><subject>Chemotherapy</subject><subject>Colonies</subject><subject>Colony-stimulating factor</subject><subject>Colorectal carcinoma</subject><subject>Cytokines</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glioma</subject><subject>Granulocyte colony-stimulating factor</subject><subject>Granulocyte Colony-Stimulating Factor - genetics</subject><subject>Granulocyte Colony-Stimulating Factor - physiology</subject><subject>Granulocytes</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Kinases</subject><subject>Leukocytes (granulocytic)</subject><subject>Lung cancer</subject><subject>Lung Neoplasms</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neutropenia</subject><subject>Neutropenia - metabolism</subject><subject>Neutrophils</subject><subject>Peripheral blood</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Receptors, Granulocyte Colony-Stimulating Factor - metabolism</subject><subject>Recombinant Proteins</subject><subject>Stem cells</subject><subject>Transcription factors</subject><subject>Tumor Microenvironment</subject><subject>Tumor necrosis factor-TNF</subject><subject>Urinary Bladder Neoplasms</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpVkctOwzAQRS0EouWxZYkssU7xI44dFkhVxUuqxKZs2FiOO25TJXFxkqLu-AV-kS8hpaWC1Yw0d85czUXogpIBVym7LsswYISRAaWEygPUpzKlESckPtz1LE1lD53U9YKQRDCRHqMeZ1QlMpF99DqZAw6-AOwdngVTtYW36waw9YWv1l8fn3WTl21hmryaYWds4wPOK5wFMHWDraksBDyFFRR-WULV3OAhDrDK4f0MHTlT1HC-q6fo5f5uMnqMxs8PT6PhOLIxVU0kwQhOU8GtZZkQDmKTCcNSNgWnhFTEWSa5TCilggjluKIxcUmWOsFikIKfotstd9lmJUxtZyKYQi9DXpqw1t7k-v-kyud65ldadkRG4g5wtQME_9ZC3eiFb0PVedaMK8mElIR2qsFWZYOv6wBuf4ESvclCd1noTRb6J4tu4fKvr7389_n8G6jxh0Y</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Liu, Li</creator><creator>Liu, Yangyang</creator><creator>Yan, Xiaohua</creator><creator>Zhou, Chong</creator><creator>Xiong, Xiangyang</creator><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20200501</creationdate><title>The role of granulocyte colony‑stimulating factor in breast cancer development: A review</title><author>Liu, Li ; Liu, Yangyang ; Yan, Xiaohua ; Zhou, Chong ; Xiong, Xiangyang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-7ea531953cc2b55fe4ab5a292def85780fc273761115058f38140f6b9f524e753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Binding sites</topic><topic>Bladder cancer</topic><topic>Blood & organ donations</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - metabolism</topic><topic>Cell adhesion & migration</topic><topic>Cell growth</topic><topic>Chemical bonds</topic><topic>Chemotherapy</topic><topic>Colonies</topic><topic>Colony-stimulating factor</topic><topic>Colorectal carcinoma</topic><topic>Cytokines</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glioma</topic><topic>Granulocyte colony-stimulating factor</topic><topic>Granulocyte Colony-Stimulating Factor - genetics</topic><topic>Granulocyte Colony-Stimulating Factor - physiology</topic><topic>Granulocytes</topic><topic>Hematopoietic stem cells</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Kinases</topic><topic>Leukocytes (granulocytic)</topic><topic>Lung cancer</topic><topic>Lung Neoplasms</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Neutropenia</topic><topic>Neutropenia - metabolism</topic><topic>Neutrophils</topic><topic>Peripheral blood</topic><topic>Phosphorylation</topic><topic>Proteins</topic><topic>Receptors, Granulocyte Colony-Stimulating Factor - metabolism</topic><topic>Recombinant Proteins</topic><topic>Stem cells</topic><topic>Transcription factors</topic><topic>Tumor Microenvironment</topic><topic>Tumor necrosis factor-TNF</topic><topic>Urinary Bladder Neoplasms</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Liu, Yangyang</creatorcontrib><creatorcontrib>Yan, Xiaohua</creatorcontrib><creatorcontrib>Zhou, Chong</creatorcontrib><creatorcontrib>Xiong, Xiangyang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Li</au><au>Liu, Yangyang</au><au>Yan, Xiaohua</au><au>Zhou, Chong</au><au>Xiong, Xiangyang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of granulocyte colony‑stimulating factor in breast cancer development: A review</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>21</volume><issue>5</issue><spage>2019</spage><epage>2029</epage><pages>2019-2029</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Granulocyte‑colony‑stimulating factor (G‑CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G‑CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G‑CSF (rhG‑CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G‑CSF plays an important role in cancer progression. G‑CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G‑CSF has an adverse effect. The current review provides an overview of G‑CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy.</abstract><cop>Greece</cop><pub>Spandidos Publications UK Ltd</pub><pmid>32186767</pmid><doi>10.3892/mmr.2020.11017</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1791-2997 |
| ispartof | Molecular medicine reports, 2020-05, Vol.21 (5), p.2019-2029 |
| issn | 1791-2997 1791-3004 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7115204 |
| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino acids Animals Binding sites Bladder cancer Blood & organ donations Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinogenesis - genetics Carcinogenesis - metabolism Cell adhesion & migration Cell growth Chemical bonds Chemotherapy Colonies Colony-stimulating factor Colorectal carcinoma Cytokines Disease Progression Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic Glioma Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - genetics Granulocyte Colony-Stimulating Factor - physiology Granulocytes Hematopoietic stem cells Humans Invasiveness Kinases Leukocytes (granulocytic) Lung cancer Lung Neoplasms Medical prognosis Metastasis Neutropenia Neutropenia - metabolism Neutrophils Peripheral blood Phosphorylation Proteins Receptors, Granulocyte Colony-Stimulating Factor - metabolism Recombinant Proteins Stem cells Transcription factors Tumor Microenvironment Tumor necrosis factor-TNF Urinary Bladder Neoplasms |
| title | The role of granulocyte colony‑stimulating factor in breast cancer development: A review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T17%3A01%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20granulocyte%20colony%E2%80%91stimulating%20factor%20in%20breast%20cancer%20development:%20A%20review&rft.jtitle=Molecular%20medicine%20reports&rft.au=Liu,%20Li&rft.date=2020-05-01&rft.volume=21&rft.issue=5&rft.spage=2019&rft.epage=2029&rft.pages=2019-2029&rft.issn=1791-2997&rft.eissn=1791-3004&rft_id=info:doi/10.3892/mmr.2020.11017&rft_dat=%3Cproquest_pubme%3E2387257701%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2387257701&rft_id=info:pmid/32186767&rfr_iscdi=true |