Door-opening motion can potentially lead to a transient breakdown in negative-pressure isolation conditions: the importance of vorticity and buoyancy airflows
A patient with severe chickenpox was admitted to a negative-pressure isolation room. He remained sedated, intubated and mechanically ventilated throughout his admission. He was managed only by nurses immune to chickenpox. A non-immune male nurse occasionally handed equipment through the doorway, wit...
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| Veröffentlicht in: | The Journal of hospital infection 2005-12, Vol.61 (4), p.283-286 |
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| container_title | The Journal of hospital infection |
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| creator | Tang, J.W. Eames, I. Li, Y. Taha, Y.A. Wilson, P. Bellingan, G. Ward, K.N. Breuer, J. |
| description | A patient with severe chickenpox was admitted to a negative-pressure isolation room. He remained sedated, intubated and mechanically ventilated throughout his admission. He was managed only by nurses immune to chickenpox. A non-immune male nurse occasionally handed equipment through the doorway, without entering the room. Ten days later, he also developed chickenpox. Sequencing of viruses from the patient and nurse showed the same rare genotype, indicating nosocomial transmission. An experimental model demonstrated that, despite negative pressure, opening the door could have resulted in transport of infectious air out of the isolation room, leading to a breakdown in isolation conditions. |
| doi_str_mv | 10.1016/j.jhin.2005.05.017 |
| format | Article |
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He remained sedated, intubated and mechanically ventilated throughout his admission. He was managed only by nurses immune to chickenpox. A non-immune male nurse occasionally handed equipment through the doorway, without entering the room. Ten days later, he also developed chickenpox. Sequencing of viruses from the patient and nurse showed the same rare genotype, indicating nosocomial transmission. An experimental model demonstrated that, despite negative pressure, opening the door could have resulted in transport of infectious air out of the isolation room, leading to a breakdown in isolation conditions.</description><identifier>ISSN: 0195-6701</identifier><identifier>EISSN: 1532-2939</identifier><identifier>DOI: 10.1016/j.jhin.2005.05.017</identifier><identifier>PMID: 16253388</identifier><language>eng</language><publisher>Kent: Elsevier Ltd</publisher><subject>Aerosol ; Air Pressure ; Biological and medical sciences ; Chickenpox ; Chickenpox - transmission ; Chickenpox - virology ; Environment, Controlled ; General aspects ; Genotype ; Herpesvirus 3, Human - genetics ; Herpesvirus 3, Human - isolation & purification ; Human infectious diseases. Experimental studies and models ; Human viral diseases ; Humans ; Infectious Disease Transmission, Patient-to-Professional ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Negative-pressure isolation room ; Nosocomial ; Patient Isolators ; Sequence Analysis, DNA ; Sequence Homology ; Transmission ; Varicella ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>The Journal of hospital infection, 2005-12, Vol.61 (4), p.283-286</ispartof><rights>2005 The Hospital Infection Society</rights><rights>2006 INIST-CNRS</rights><rights>Copyright © 2005 The Hospital Infection Society. Published by Elsevier Ltd. 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He remained sedated, intubated and mechanically ventilated throughout his admission. He was managed only by nurses immune to chickenpox. A non-immune male nurse occasionally handed equipment through the doorway, without entering the room. Ten days later, he also developed chickenpox. Sequencing of viruses from the patient and nurse showed the same rare genotype, indicating nosocomial transmission. An experimental model demonstrated that, despite negative pressure, opening the door could have resulted in transport of infectious air out of the isolation room, leading to a breakdown in isolation conditions.</description><subject>Aerosol</subject><subject>Air Pressure</subject><subject>Biological and medical sciences</subject><subject>Chickenpox</subject><subject>Chickenpox - transmission</subject><subject>Chickenpox - virology</subject><subject>Environment, Controlled</subject><subject>General aspects</subject><subject>Genotype</subject><subject>Herpesvirus 3, Human - genetics</subject><subject>Herpesvirus 3, Human - isolation & purification</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Patient-to-Professional</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Negative-pressure isolation room</subject><subject>Nosocomial</subject><subject>Patient Isolators</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology</subject><subject>Transmission</subject><subject>Varicella</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0195-6701</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU2LFDEQDaK44-of8CC56K3HpJP0h4gg664KC170HDJJZSZjd9Im6Vnmz_hbTTODqxeFglTVe_WoykPoOSVrSmjzer_e75xf14SI9RK0fYBWVLC6qnvWP0QrQntRNS2hF-hJSntCSOmLx-iCNrVgrOtW6OeHEGIVJvDOb_EYsgsea-XxFDL47NQwHPEAyuAcsMI5Kp9cAfAmgvpuwp3HzmMPW5XdAaopQkpzBOxSGNRJLHjjliy9wXlXkHEKMSuvAQeLDyV32uUjVt7gzRyOBSmFi3YId-kpemTVkODZ-b1E326uv159qm6_fPx89f620oLyXHGuhQIKum85Icw0XHADhNeWdi2vxUZpYoUAMKLpKbU9s9pa0zYMjDbEsEv07qQ7zZux9MqFUQ1yim5U8SiDcvJvxLud3IaDbCnlPSdF4NVZIIYfM6QsR5c0DIPyEOYkm65rSMvEf4k16URN-6YQ6xNRx5BSBPt7G0rk4r_cy8V_ufgvl6BtGXrx5x33I2fDC-HlmaCSVoMtfmqX7nkto3XDlnvennhQfv3gIMqki-8ajIugszTB_WuPX-cC1M4</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Tang, J.W.</creator><creator>Eames, I.</creator><creator>Li, Y.</creator><creator>Taha, Y.A.</creator><creator>Wilson, P.</creator><creator>Bellingan, G.</creator><creator>Ward, K.N.</creator><creator>Breuer, J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>The Hospital Infection Society. Published by Elsevier Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20051201</creationdate><title>Door-opening motion can potentially lead to a transient breakdown in negative-pressure isolation conditions: the importance of vorticity and buoyancy airflows</title><author>Tang, J.W. ; Eames, I. ; Li, Y. ; Taha, Y.A. ; Wilson, P. ; Bellingan, G. ; Ward, K.N. ; Breuer, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-44c5ae1ec974003d6454de042f187425bac0f55eed56911f93fcffd763edcd0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aerosol</topic><topic>Air Pressure</topic><topic>Biological and medical sciences</topic><topic>Chickenpox</topic><topic>Chickenpox - transmission</topic><topic>Chickenpox - virology</topic><topic>Environment, Controlled</topic><topic>General aspects</topic><topic>Genotype</topic><topic>Herpesvirus 3, Human - genetics</topic><topic>Herpesvirus 3, Human - isolation & purification</topic><topic>Human infectious diseases. 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| ispartof | The Journal of hospital infection, 2005-12, Vol.61 (4), p.283-286 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aerosol Air Pressure Biological and medical sciences Chickenpox Chickenpox - transmission Chickenpox - virology Environment, Controlled General aspects Genotype Herpesvirus 3, Human - genetics Herpesvirus 3, Human - isolation & purification Human infectious diseases. Experimental studies and models Human viral diseases Humans Infectious Disease Transmission, Patient-to-Professional Infectious diseases Male Medical sciences Middle Aged Negative-pressure isolation room Nosocomial Patient Isolators Sequence Analysis, DNA Sequence Homology Transmission Varicella Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Door-opening motion can potentially lead to a transient breakdown in negative-pressure isolation conditions: the importance of vorticity and buoyancy airflows |
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