Mutation of neutralizing/antibody-dependent enhancing epitope on spike protein and 7b gene of feline infectious peritonitis virus: Influences of viral replication in monocytes/macrophages and virulence in cats

We previously prepared neutralizing monoclonal antibody (MAb)-resistant (mar) mutant viruses using a laboratory strain feline infectious peritonitis virus (FIPV) 79-1146 (Kida et al., 1999). Mar mutant viruses are mutated several amino acids of the neutralizing epitope of Spike protein, compared wit...

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Veröffentlicht in:	Virus research 2011-03, Vol.156 (1-2), p.72-80
Hauptverfasser:	Takano, Tomomi, Tomiyama, Yoshika, Katoh, Yasuichiroh, Nakamura, Michiyo, Satoh, Ryoichi, Hohdatsu, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution amino acids Animals Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibody-dependent enhancement Cats Cells, Cultured Coronavirus, Feline - genetics Coronavirus, Feline - immunology Coronavirus, Feline - pathogenicity epitopes Epitopes - genetics Epitopes - immunology Feline coronavirus Feline infectious peritonitis Feline Infectious Peritonitis - immunology Feline Infectious Peritonitis - virology Feline infectious peritonitis virus genes Genome, Viral Macrophage macrophages Macrophages - virology monoclonal antibodies Monoclonal antibody-resistant mutant virus Monocyte monocytes Monocytes - virology mutants Mutation neutralization nucleotides sequence deletion Survival Analysis Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology virulence Virulence - genetics virus replication Virus Replication - physiology viruses
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