GSK983: A novel compound with broad-spectrum antiviral activity

GSK983, a novel tetrahydrocarbazole, inhibits the replication of a variety of unrelated viruses in vitro with EC 50 values of 5–20 nM. Both replication of the adenovirus Ad-5 and the polyoma virus SV-40, and episomal maintenance of human papillomaviruses (HPV) and Epstein-Barr virus (EBV) are suscep...

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Veröffentlicht in:	Antiviral research 2009-04, Vol.82 (1), p.1-11
Hauptverfasser:	Harvey, Robert, Brown, Kevin, Zhang, Qin, Gartland, Margaret, Walton, Leslie, Talarico, Christine, Lawrence, Wendell, Selleseth, Dean, Coffield, Neil, Leary, Jeffry, Moniri, Kelly, Singer, Sara, Strum, Jay, Gudmundsson, Kristjan, Biron, Karen, Romines, Karen R., Sethna, Phiroze
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Carbazoles - pharmacology Cell Line, Transformed Cell Transformation, Viral Cells, Cultured DNA Viruses - drug effects DNA Viruses - physiology Epstein-Barr virus GSK983 Herpes simplex virus 1 Human immunodeficiency virus Human papillomavirus Human T-lymphotropic virus 1 Humans Interferon-stimulated genes Medical sciences Novel antiviral Pharmacology. Drug treatments Polyomavirus Simian virus 40 Tetrahydrocarbazole Virus Replication - drug effects
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