Resources to Discover and Use Short Linear Motifs in Viral Proteins

Viral proteins evade host immune function by molecular mimicry, often achieved by short linear motifs (SLiMs) of three to ten consecutive amino acids (AAs). Motif mimicry tolerates mutations, evolves quickly to modify interactions with the host, and enables modular interactions with protein complexe...

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2020-01, Vol.38 (1), p.113-127
Hauptverfasser:	Hraber, Peter, O’Maille, Paul E., Silberfarb, Andrew, Davis-Anderson, Katie, Generous, Nicholas, McMahon, Benjamin H., Fair, Jeanne M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs - immunology Amino acids Animals Antigens Apoptosis Autophagy B-Lymphocytes - immunology Biosecurity cell signaling Conserved sequence Evolution Gene Ontology Host-Pathogen Interactions - immunology host–pathogen interactions Humans immune modulation Immune response Information resources Interfaces Kinases Knowledge management Management tools Mimicry molecular mimicry Molecular Mimicry - immunology Mutation Ontology Pathogens Proteins Review short linear motifs Signal transduction Signal Transduction - immunology Synthetic Biology Tumor necrosis factor-TNF Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - immunology Viruses
Online-Zugang:	Volltext
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