Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus
Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. In parallel, lithium chloride (LiCl), a chemical reagent...
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| Veröffentlicht in: | Antiviral research 2010-02, Vol.85 (2), p.346-353 |
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| creator | Sui, Xiuwen Yin, Jiechao Ren, Xiaofeng |
| description | Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ability against PrV infection in vitro. Virus plaque-reduction assays, PCR and RT-PCR analysis indicated that both drugs inhibited cell infection by PrV. Moreover, addition of the drugs resulted in fewer apoptotic cells during PrV infection. |
| doi_str_mv | 10.1016/j.antiviral.2009.10.014 |
| format | Article |
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In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ability against PrV infection in vitro. Virus plaque-reduction assays, PCR and RT-PCR analysis indicated that both drugs inhibited cell infection by PrV. Moreover, addition of the drugs resulted in fewer apoptotic cells during PrV infection.</description><identifier>ISSN: 0166-3542</identifier><identifier>EISSN: 1872-9096</identifier><identifier>DOI: 10.1016/j.antiviral.2009.10.014</identifier><identifier>PMID: 19879899</identifier><identifier>CODEN: ARSRDR</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Antiviral Agents - pharmacology ; Apoptosis ; Biological and medical sciences ; Cell Survival ; Chlorocebus aethiops ; Diammonium glycyrrhizinate ; Glycyrrhiza - chemistry ; Glycyrrhiza glabra ; Glycyrrhizic Acid - pharmacology ; Herpesvirus ; Herpesvirus 1, Suid - drug effects ; Lithium chloride ; Lithium Chloride - pharmacology ; Medical sciences ; Molecular Structure ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Polymerase Chain Reaction ; Pseudorabies virus ; Pseudorabies virus (PrV) ; Reverse Transcriptase Polymerase Chain Reaction ; Vero Cells ; Viral Plaque Assay</subject><ispartof>Antiviral research, 2010-02, Vol.85 (2), p.346-353</ispartof><rights>2009 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier B.V. All rights reserved.</rights><rights>Copyright © 2009 Elsevier B.V. All rights reserved. 2009 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-e538a606e0f8b7584ccf30618de6b4156cc93a2e97933cdaa6ca265a4867885b3</citedby><cites>FETCH-LOGICAL-c602t-e538a606e0f8b7584ccf30618de6b4156cc93a2e97933cdaa6ca265a4867885b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166354209005014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22397102$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19879899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sui, Xiuwen</creatorcontrib><creatorcontrib>Yin, Jiechao</creatorcontrib><creatorcontrib>Ren, Xiaofeng</creatorcontrib><title>Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus</title><title>Antiviral research</title><addtitle>Antiviral Res</addtitle><description>Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ability against PrV infection in vitro. Virus plaque-reduction assays, PCR and RT-PCR analysis indicated that both drugs inhibited cell infection by PrV. Moreover, addition of the drugs resulted in fewer apoptotic cells during PrV infection.</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Chlorocebus aethiops</subject><subject>Diammonium glycyrrhizinate</subject><subject>Glycyrrhiza - chemistry</subject><subject>Glycyrrhiza glabra</subject><subject>Glycyrrhizic Acid - pharmacology</subject><subject>Herpesvirus</subject><subject>Herpesvirus 1, Suid - drug effects</subject><subject>Lithium chloride</subject><subject>Lithium Chloride - pharmacology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Polymerase Chain Reaction</subject><subject>Pseudorabies virus</subject><subject>Pseudorabies virus (PrV)</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Vero Cells</subject><subject>Viral Plaque Assay</subject><issn>0166-3542</issn><issn>1872-9096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAUhSMEYsrAXwBvEKsUO0782CBVIxiQRmIDa8txbqa3SuyOnVTq_HoctVNgNSs_zneP7_Upig-Mrhll4vNubf2EB4x2WFeU6ny7pqx-UayYklWpqRYvi1UmRcmburoq3qS0o5QKqdXr4opplTdar4qHzZMPgb4HN5HQkw7tOAaP80juh6M7xrjFR_R2AmJ9RwactovmtkOI2AEJnjgYBoJ-ccB8bI9kn2DuQrQtQiJbiHtI-Z05vS1e9XZI8O68Xhe_v339dfO9vPt5--Nmc1c6QauphIYrK6gA2qtWNqp2rudUMNWBaGvWCOc0txVoqTl3nbXC2Uo0tlZCKtW0_Lr4cvLdz-0InQM_5SnNPuJo49EEi-Z_xePW3IeDkYzVjMls8OlsEMPDDGkyI6ZlTushzMkoKRtJhWqeJSXnitWNEJmUJ9LFkFKE_tIPo2ZJ1uzMJVmzJLsIOdlc-f7fcf7WnaPMwMczYJOzQx-td5guXFVxLRmtMrc5cZA__4AQTXII3kGHMadnuoDPNvMHSOPKNw</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Sui, Xiuwen</creator><creator>Yin, Jiechao</creator><creator>Ren, Xiaofeng</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus</title><author>Sui, Xiuwen ; Yin, Jiechao ; Ren, Xiaofeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-e538a606e0f8b7584ccf30618de6b4156cc93a2e97933cdaa6ca265a4867885b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cell Survival</topic><topic>Chlorocebus aethiops</topic><topic>Diammonium glycyrrhizinate</topic><topic>Glycyrrhiza - chemistry</topic><topic>Glycyrrhiza glabra</topic><topic>Glycyrrhizic Acid - pharmacology</topic><topic>Herpesvirus</topic><topic>Herpesvirus 1, Suid - drug effects</topic><topic>Lithium chloride</topic><topic>Lithium Chloride - pharmacology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Polymerase Chain Reaction</topic><topic>Pseudorabies virus</topic><topic>Pseudorabies virus (PrV)</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Vero Cells</topic><topic>Viral Plaque Assay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sui, Xiuwen</creatorcontrib><creatorcontrib>Yin, Jiechao</creatorcontrib><creatorcontrib>Ren, Xiaofeng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antiviral research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sui, Xiuwen</au><au>Yin, Jiechao</au><au>Ren, Xiaofeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus</atitle><jtitle>Antiviral research</jtitle><addtitle>Antiviral Res</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>85</volume><issue>2</issue><spage>346</spage><epage>353</epage><pages>346-353</pages><issn>0166-3542</issn><eissn>1872-9096</eissn><coden>ARSRDR</coden><abstract>Diammonium glycyrrhizin (DG), a salt from glycyrrhizinate (GL) that is a major active component of licorice root extract with various pharmacological activities was investigated for its inhibitory effect on pseudorabies virus (PrV) infection. 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| ispartof | Antiviral research, 2010-02, Vol.85 (2), p.346-353 |
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| language | eng |
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| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Apoptosis Biological and medical sciences Cell Survival Chlorocebus aethiops Diammonium glycyrrhizinate Glycyrrhiza - chemistry Glycyrrhiza glabra Glycyrrhizic Acid - pharmacology Herpesvirus Herpesvirus 1, Suid - drug effects Lithium chloride Lithium Chloride - pharmacology Medical sciences Molecular Structure Pharmacology. Drug treatments Plant Extracts - pharmacology Plant Roots - chemistry Polymerase Chain Reaction Pseudorabies virus Pseudorabies virus (PrV) Reverse Transcriptase Polymerase Chain Reaction Vero Cells Viral Plaque Assay |
| title | Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus |
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