Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine

Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal piglets. In Asia, modified live attenuated vaccines have been used to control PE...

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Veröffentlicht in:	Antiviral research 2018-10, Vol.158, p.199-205
Hauptverfasser:	Chu, Hsu-Feng, Chen, Chiao-Che, Moses, David C., Chen, Yau-Hung, Lin, Chao-Hsiung, Tsai, Ying-Chieh, Chou, Chi-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Thioguanine Alpha coronavirus Antiviral Agents - pharmacology Binding Sites - drug effects Coronavirus - drug effects Coronavirus Infections Coronavirus Papain-Like Proteases Kinetics Molecular Docking Simulation Noncompetitive inhibition Papain - antagonists & inhibitors Papain - chemistry Papain - genetics Papain - isolation & purification Papain-like protease PEDV Porcine epidemic diarrhea virus - drug effects Porcine epidemic diarrhea virus - genetics Protein Conformation - drug effects Recombinant Proteins Thioguanine - pharmacology
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