The molecular tweezer CLR01 inhibits Ebola and Zika virus infection

Ebola (EBOV) and Zika viruses (ZIKV) are responsible for recent global health threats. As no preventive vaccines or antiviral drugs against these two re-emerging pathogens are available, we evaluated whether the molecular tweezer CLR01 may inhibit EBOV and ZIKV infection. This small molecule has pre...

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Veröffentlicht in:	Antiviral research 2018-04, Vol.152, p.26-35
Hauptverfasser:	Röcker, Annika E., Müller, Janis A., Dietzel, Erik, Harms, Mirja, Krüger, Franziska, Heid, Christian, Sowislok, Andrea, Riber, Camilla Frich, Kupke, Alexandra, Lippold, Sina, von Einem, Jens, Beer, Judith, Knöll, Bernd, Becker, Stephan, Schmidt-Chanasit, Jonas, Otto, Markus, Vapalahti, Olli, Zelikin, Alexander N., Bitan, Gal, Schrader, Thomas, Münch, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Bridged-Ring Compounds - pharmacology Broadly active antiviral agents Cell Line Chlorocebus aethiops Ebola virus Ebolavirus - drug effects Ebolavirus - genetics Ebolavirus - physiology Hemorrhagic Fever, Ebola - virology Humans Lipid rafts Organophosphates - pharmacology Vero Cells Virus inactivation Virus Replication - drug effects Zika virus Zika Virus - drug effects Zika Virus - genetics Zika Virus - physiology Zika Virus Infection - virology
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